丹参对实验性肝硬化细胞外基质影响的免疫组化观察  

IMMUNLLOGIC HISTOCHEMISTRY STUDIES ON THE EFFECT OF EXTRACELLULAR MATRIX OF SALVIAE MILTIORRHIZAE(SM)ON EXPERIMENTAL CIRRHOSIS

作　　者：马学惠[1] 龚爱玉[1] 尹镭[1] 陈贤明[1] 赵元昌[1] 王蕊[1] 韩德五[1] 

机构地区：[1]山西医学院肝病研究所

出　　处：《肝脏病杂志》1994年第2期79-81,共3页

摘　　要：结果显示，实验８周末对照组动物全部形成肝硬化，肝胶原蛋白含量升高，纤维连接蛋白及层粘连蛋白量从２周起逐渐增加，８周末最明显，结蛋白阳性细胞２至６周增加，８周末减少，显示已转变为成纤维细胞。经丹参治疗的动物无一只发生肝硬化，肝内胶原蛋白含量，纤维连接蛋白及层粘连蛋白含量均明显低于对照组，结蛋白阳性细胞２至６周低而８周末高于对照组，提示丹参可减轻实验性肝硬化动物细胞外基质的产生，并减少贮脂细胞转化为成纤维细胞。The results Indicated that all the rats in control group developed cirrhosis accompanied with increment of hepatic collagen after injection CCI4 and dietetic injury for 8 weeks. Fibronectin and laminin contents in liver were increased gradually,but desmin positive cells were increased from 2 to 6 weeks,decreased after 8 weeks which indicated that DM+2 cells transformed to fibroblasts. There was no rat developed cirrhosis in SM trent- ing group. The contents of hepatic collagen,FN and LN were lower significantly in SM group compared with controls. DM+ cells were lower from 2 to6 weeks, but it was higher than controls after 8 weeks. The results indicated that SM could decrease the contents of extracellular matrix and DM+ cells transfoming fibroblasts in experimental cirrhosis.

关 键 词：肝硬化 纤维连接蛋白 层粘连蛋白 结蛋白 丹参 

分 类 号：R285.5[医药卫生—中药学] R259.752[医药卫生—中医学]