缓慢成孔型磷酸钙复合材料的性能研究  

Study on performance of gradually hole-forming calcium phosphate polymer

作　　者：王剑龙[1] 黄龄瑾[2] 肖飞[1] 郑治[1] 

机构地区：[1]中南大学湘雅三医院骨科,长沙410013 [2]广西医科大学病理生理学教研室,广西南宁530021

出　　处：《广西大学学报（自然科学版）》2005年第2期135-138,150,共5页Journal of Guangxi University（Natural Science Edition）

基　　金：国家自然科学基金CPC-PLGA复合体构建组织工程化骨的实验研究(30370412)

摘　　要：目的制备并检测CPC-PLGA复合物,为骨组织工程研究提供新的支架材料.方法制备CPC-PLGA复合物,筛选最佳配比并检测其性能;将人骨髓间充质干细胞种植于CPC-PLGA复合物上并体外培养,然后进行扫描电镜观察.结果CPC-30%vol%PLGA力学性能最好,抗压强度40.5MPa,弹性模量13.8Gpa;模拟体液下降解6周材料形成100～300μm相互连通孔隙;骨髓间充质干细胞在支架材料表面生长良好,并通过降解产生的孔洞内材料深部长入.结论CPC-PLGA复合支架材料具有优良特性,适于骨组织工程支架.Objective Preparing and testing CPC-PLGA polymer tissue engineered bone ,providing a new-type scaffold material for Bone Tissue Engineering.Methods Prepared CPC-PLGA polymer,choosed the best proportion and tested its performance; Human bone marrow mesenchymal sten cells(BMSCs) were seeded into CPC-PLGA polymer and cultured in vitro,then detected by SEM.Results CPC-30%vol%PLGA had the best mechanical capability,σ=40.5 Mpa,Ε =13.8 Gpa;Intercommunicative holes which size was among 100 μm～300 μm was observed in polymer after its degradation in simulative body fluid for 6 weeks; BMSCs could grow on the material surface well,moreover develop toward interior via the hole formed with degradation.Conclusion Fine performance was found in CPC-PLGA polymer and this material could be made for bone tissue engineering scaffold.

关 键 词：支架材料 CPC—PLGA复合物 骨髓间充质干细胞 骨组织工程 

分 类 号：R687[医药卫生—骨科学]