盐酸曲马多在大鼠体内的分布特点  

Distribution of Tramadol Hydrochloride in Rats

作　　者：张楠[1] 贠克明[1] 贺文艳[1] 尉志文[1] 陈朝阳[1] 王玉瑾[1] 王大利[2] 郭红民[3] 

机构地区：[1]山西医科大学法医学院,山西太原030001 [2]太原市公安局,山西太原030001 [3]太原市公安局迎泽分局,山西太原030001

出　　处：《中国法医学杂志》2005年第3期143-145,共3页Chinese Journal of Forensic Medicine

摘　　要：目的观察盐酸曲马多在大鼠体内的分布及其特点。方法大鼠以3倍和6倍LD50228mg/kg剂量盐酸曲马多灌胃染毒致死,取材,薄层色谱法检测其心、肺、肝、脾、肾、大脑和血内盐酸曲马多的浓度。结果3倍LD50剂量组大鼠肾、肺、血、肝、大脑、脾和心组织盐酸曲马多的浓度分别为112±15、59±17、53±31、32±19.7、22±11.5、20±20、16.7±8.3μg/g或μg/ml;6倍LD50剂量组大鼠血、肺、肝、心、肾、大脑和脾中盐酸曲马多的浓度分别为107.6±7.2、26.3±20、11.7±6.6、11.2±7.2、10.3±3.6、6.38±0.2、6.1±0.3μg/g或μg/ml。结论3倍LD50剂量组大鼠,肾、肺、血内盐酸曲马多浓度最高;6倍LD50剂量组大鼠血、肺、肝中盐酸曲马多的浓度最高。盐酸曲马多中毒时,血、肝、肺和肾可以作为法医毒物分析的检材。Objective To investigate the in vivo distribution of tramadol hydrochloride in rats. Methods After an oral administration of tramadol hydrochloride (684 or 1368 mg/kg), concentrations of tramadol hydrochloride in the heart, lung, liver, kidney, spleen, brain and blood were determined by a TLC scanning chromatography. Results The levels of tramadol hydrochloride in the kidney , lung , blood , liver , brain , spleen and heart were 112±15, 59±17, 53±31, 32±19.7, 22±11.5, 20±20, 16.7±8.3 μg/g (μg/ml) in the rats given three times LD 50 dose ( 684 mg/kg) respectively, and the concentrations of tramadol hydrochloride in the blood, lung , liver, heart, kidney, brain and spleen in rats given six times LD 50 dose (1368 mg/kg) was 107.6±7.2, 26.3±20, 11.7±6.6, 11.2±7.2, 10.3±3.6, 6.38±0.2, 6.1±0.3 μg/g (μg/ml) respectively . Conclusion In rats with three times LD 50 dose, the levels of tramadol hydrochloride in kidney, lung, blood are higher, whereas in the rats with six times LD 50 dose, the higher concentrations of tramadol hydrochloride are determined in the blood, lung and liver, suggesting that blood, liver, lung, kidney and spleen are suitable samples for forensic toxicological analysis in tramadol hydrochloride poisoning cases.

关 键 词：法医毒物分析 盐酸曲马多 薄层色谱 药物分布 

分 类 号：R89[医药卫生—法医学]