肿瘤坏死因子基因多态性与Graves病的相关性研究  

Association of TNFɑ gene polymorphism with Graves disease

作　　者：江维岩[1] 蒋玲[1] 龚莹[2] 

机构地区：[1]山东大学齐鲁医院内分泌科,山东济南250012 [2]徐州医学院第二附属医院内分泌科,江苏徐州221000

出　　处：《山东大学学报（医学版）》2005年第6期500-503,共4页Journal of Shandong University:Health Sciences

基　　金：山东省卫生厅基金资助项目(2001CA1CJB10)

摘　　要：目的:探讨肿瘤坏死因子(TNF)基因多态性与Graves病(GD)的关系。方法:用序列特异性引物聚合酶链反应技术(PCR-SSP)检测TNF等位基因及基因型。结果:TNF+488、-308等位基因及基因型分布在GD组与健康对照组之间、在不同性别、有无GD家族史、有无甲状腺相关眼病(TAO)GD亚组之间差异无统计学意义。结论:TNF+488、-308基因多态性与山东汉族GD患者发病无关联。Objcetive: To investigate the association of the polymorphisms of tumour necrosis factor (TNF)-ɑ gene with Graves disease (GD). Method: Allele and genotype frequencies were determined by polymerase chain reaction and sequence specific primers (PCR-SSP). Result: Allele and genotype frequencies of TNFɑ +488, -308 were not significantly different between GD and control groups. There were also no significant difference between male and female GD, GD with and without GD familial history, GD with and without thyroid-related ophthalmopath (TAO) groups. Conclusion: There are no association between polymorphisms of TNFɑ +488, -308 genes and GD susceptibility in Hans nationals in Shandong Chinese.

关 键 词：肿瘤坏死因子 GRAVES病 基因表达 多态现象 

分 类 号：Q343.12[生物学—遗传学]