老瓜头生物总碱镇痛、抗炎作用的实验研究  

Effects of Anti-inflammation and Ache Easing of Total Alkaloid of Cynanchum Komarovii AI Iljinski

作　　者：杨卫东[1] 郝银菊[2] 李红兵[1] 孙伟[1] 吴璟[1] 

机构地区：[1]宁夏医学院实验动物中心,银川750004 [2]宁夏医学院教务处,银川750004

出　　处：《宁夏医学院学报》2005年第3期191-193,共3页Journal of Ningxia Medical College

基　　金：宁夏回族自治区科技厅资助项目

摘　　要：目的研究老瓜头生物碱的急性毒性及镇痛、抗炎作用。方法应用扭体法、热板法观察老瓜头生物碱对小鼠的镇痛作用;应用蛋清致大鼠足趾肿、大鼠棉球肉芽肿及对大鼠足趾炎症组织内前列腺素E2(PGE2)的影响,观察老瓜头生物碱的镇痛、抗炎作用。结果老瓜头生物碱对小鼠扭体次数,热板法对小鼠舔足时间有明显的抑制作用;对蛋清致大鼠足趾肿、大鼠棉球肉芽肿及对大鼠足趾炎症组织内PGE2的含量,均有明显的抑制作用。结论老瓜头生物碱具有镇痛、抗炎作用,此作用与抑制炎症组织内的PGE2有关,此作用的强度与吲哚美辛、氢化可的松相似或略强。Objective To study the acute toxicity and the effects of inf la mmation resisting and ache easing of Total Alkaloid of Cynanchum Komarovii AI. I l jinski. Methods Mouse twisting method and hot-plate method were adopted to observe the ache easing effects of Total Alkaloid of CK. The paw ed ema caused by egg-albumen and tampon-acestoma of rat were used to observe the effects of the ache easing and inflammation resisting of Total Alkaloid of CK an d the variance of PGE2 in paw edema was tested. Results Tota l Alkaloid of CK restrained rat twisting times and licking feet times in mouse t wisting method and hot-plate method, respectively. It obviously restrained the paw edema of rat, tampon-acestoma and the level of PGE2 in inflammatory tiss ue of paw edema. Conclusion Total Alkaloid of CK has the effect s of ache easing and inflammation resisting. These effects are correlated to th e restrained level of PGE2 in inflammatory tissue. The strength of these effe cts are similar to or a little stronger than indomethacin and hydrocortisone.

关 键 词：老瓜头生物碱 镇痛作用 抗炎作用 前列腺素E2 

分 类 号：R285.5[医药卫生—中药学]