女性系统性红斑狼疮病人性激素水平  

Sex hormones in female patients with systemic lupus erythematosus

作　　者：蒋姣伏[1] 柳永和[2] 张传兴[2] 

机构地区：[1]中南大学湘雅二医院检验科,长沙410011 [2]中南大学医学技术与情报学院医学检验系,长沙410013

出　　处：《中南大学学报（医学版）》2005年第3期315-317,共3页Journal of Central South University ：Medical Science

摘　　要：目的:探讨女性系统性红斑狼疮(SLE)病人性激素水平及其在SLE发病中的作用。方法:采取电化学法检测98例SLE病人血清雌二醇(E2)、雌三醇(E3)、睾酮(T)、孕酮(Prog)和泌乳素(PRL),并与36例健康妇女作对照。结果:SLE病人组E2,E3,Prog和PRL明显高于对照组(P<0.05);25～34岁SLE病人E2,Prog,PRL水平较其它年龄组和对照组为高(均P<0.05),且活动期E2和PRL明显高于稳定期(P<0.05)。结论:性激素与SLE的发生发展密切相关。Objective To explore the levels of sex hormones in female patients with systemic lupus erythematosus (SLE) and its role in the genesis of SLE. Methods The serum levels of estradiol, estriol, testosterone, progesterone, and prolactin were determined by electro-chemiluminescence immunoassay in 98 female patients with SLE and compared with those of 38 healthy women. Results The serum levels of estradiol, estriol, progesterone, and prolactin were significantly higher than those in the healthy women (P< 0.05). The serum levels of estradiol, progesterone, and prolactin in patients with SLE in 25 to 34 year old group were higher than the other age groups and the control group (P<0.05), and the serum levels of estradiol and prolactin in patients with active phase of SLE were significantly higher than those in patients with stable phase of SLE (P<0.05). Conclusion The levels of sex hormones have a close corretation with the genesis and development of SLE.

关 键 词：系统性红斑狼疮 性激素 电化学测定法 女性 

分 类 号：R593.241[医药卫生—内科学]