祛瘀消斑胶囊对动脉粥样硬化血管内皮功能失调的保护作用  

Protective Effect of Quyu Xiaoban Capsule on Endothelial Dysfunction of Patients with Artherosclerosis

作　　者：刘运芳[1] 赵玉霞[2] 于会明[1] 黄涛[1] 郑玉兰[1] 宋文延[1] 

机构地区：[1]山东大学医学院,山东济南250012 [2]山东大学齐鲁医院,山东济南250012

出　　处：《南京中医药大学学报》2005年第4期223-225,共3页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：山东省卫生厅"九五"重点攻关项目(9711)

摘　　要：目的观察祛瘀消斑胶囊对动脉粥样硬化(AS)患者血脂、一氧化氮(NO)、内皮素1(ET-1)及血管内皮功能的影响。方法80例AS患者随机分为实验组和对照组,超声检测血管内皮功能,并测定其血脂、NO及ET-1水平。结果治疗后实验组TC及LDL-C显著降低,且LDL-C显著低于对照组;实验组NO较治疗前及对照组显著升高,ET-1较治疗前显著降低(P<0.05);治疗后实验组反应性充血引起肱动脉内径的舒张较治疗前及对照组显著改善,而2组间肱动脉内径基础值和含服硝酸甘油后肱动脉内径的舒张无显著性差异。结论祛瘀消斑胶囊能显著降低血脂水平,改善NO/ET-1失衡及内皮依赖性血管舒张功能。OBJECTIVE To observe the effect of Quyu Xiaoban Capsule on blood lipid, nitrogen oxide (NO), endothelin 1 (ET - 1) and the function of endothelium in patients with artherosclerosis (AS). METHOD 80 patients were divided randomly into an experiment group and a control group, who were given ultrasonic examination on endothelium function and determination of the levels of blood lipid, NO and ET - 1. RESULT After the treatment, the levels of TC and LDL - C in the experiment group dropped markedly, with LDL- C level significantly lower than the control group. In the experiment group, NO level rose compared with the control group and ET - 1 level dropped markedly ( P < 0.05) . CONCLUSION Quyu Xiaoban Capsule can markedly reduce blood lipid level, prevent NO/ET - 1 imbalance and improve the diastole function of dependent blood vessels.

关 键 词：动脉粥样硬化 祛瘀消斑胶囊 血管内皮功能障碍 

分 类 号：R285.6[医药卫生—中药学]