复方乳酸左氧氟沙星阴道栓的急性毒性研究  

Study on acute viginal toxicity of Compound Levofloxacin Lactate Vaginal Suppository

作　　者：纪忠岐[1] 闫志玲 包翠屏[1] 董福祥[3] 

机构地区：[1]河南大学药学院药理教研室,河南开封475001 [2]开封市卫校附属医院药剂科,河南开封475000 [3]河南省人民医院药械科,河南郑州450003

出　　处：《河南大学学报（医学版）》2005年第2期37-37,41,共2页Journal of Henan University:Medical Science

摘　　要：目的观察复方乳酸左氧氟沙星阴道栓对家兔1次性给药后对家兔阴道的急性反应及动物死亡情况。方法将家兔仰卧固定,于阴道内1次置入药物0.2g/kg.使药物与阴道黏膜接触6h,观察动物给药后即刻及14d内动物的全身反应情况。结果给药后,动物无死亡和全身毒性反应。结论复方乳酸左氧氟沙星阴道栓对家兔的急性毒性实验无发现明显毒性反应。Objective: To observe the acute reacts and death number of animals when Compound Levofloxacin Lactate Vaginal Suppository was given to rabbit for only one time. Methods: Rabbit was fastened supine, medicine was put into vagina with a dose of 0.2 g/kg one time, medicine was kept in touch with vaginal mucous membrane for six hours, and the systemic reacts were observed at once and in fourteen days. Results: No animal died and had systemic toxicity reacts after the medicine was given. Conclusion: No evident toxicity reacts were found during the acute and toxicity experiment for rabbit given by Compound Levofloxacin Lactate Vaginal Suppository.

关 键 词：复方乳酸左氧氟沙星 阴道栓 阴道黏膜 急性毒性 

分 类 号：R965.3[医药卫生—药理学]