高效液相色谱法测定氯诺昔康速释片的含量  

Determination of Lornoxicam Rapid Film-coated Tablets by HPLC

作　　者：黄剑英[1] 杨红娟[1] 

机构地区：[1]厦门市药品检验所,厦门361012

出　　处：《海峡药学》2005年第3期55-56,共2页Strait Pharmaceutical Journal

摘　　要：目的建立了氯诺昔康速释片含量的HPLC测定法。方法采用C18色谱柱,柱温35℃,流动相为0.1mol·L-1醋酸钠溶液-甲醇(1∶1),检测波长为378nm。结果氯诺昔康在9.5μg·mL^285.5μg·mL范围内线性良好,相关系数r=1.0000(n=5);平均回收率为99.69%(n=6,RSD为0.9%)。结论HPLC法可以测定氯诺昔康速释片的含量。OBJECTIVE A HPLC method with differential detector for determination of lornoxicam rapid film-coated tablets was presented.METHODS A C_ 18 (250mm×4.6mm,5μm)column was used with mobile phase of 0.1mol·L -1 Sodium Acetate-methanol(1∶1)at detection wavelength of 378nm;The temperature of column was 35℃.RESULTS The calibration curve was liner in the concentration rang of 9.5μg·mL～285.5μg·mL,r=1.0000(n=5);The average recovery was 99.6% with a relative standard deviation of 0.9%(n=6).CONCLUSION The HPLC method is Determination of Lornoxicam.

关 键 词：氯诺昔康 高效液相色谱 速释片 测定 

分 类 号：R927.2[医药卫生—药学]