两种稀土纳米材料对红细胞脆性的影响  

The Effect of Two Kinds of Rare Earth Nano Materials on Erythrocytr Brittleness

作　　者：秦泗霞[1] 苏冬梅[2] 马建伟[1] 

机构地区：[1]青岛大学纺织服装学院,山东青岛266071 [2]青岛大学医学院,山东青岛266071

出　　处：《青岛大学学报（工程技术版）》2005年第2期50-52,共3页Journal of Qingdao University(Engineering & Technology Edition)

基　　金：山东省自然科学基金资助项目(Y2001F04)

摘　　要：为研究稀土纳米材料对红细胞脆性的影响,以豚鼠作为实验对象,将稀土纳米材料配成质量浓度分别为100g/L和500g/L的两种溶液,通过皮肤接触、口腔摄入、静脉注射和肌肉注射4种途径作用于豚鼠,采用红细胞脆性试验观察了动物血液指标之一———红细胞脆性的变化。结果发现,豚鼠接触该类稀土纳米材料后,红细胞的脆性与对照组相比升高。这说明稀土纳米材料对红细胞膜的结构产生了破坏,同时红细胞脆性的增加也表明该材料在豚鼠体内引起了遗传性球形红细胞增多症或自身免疫性溶血性贫血等疾病。To study the effect of rare earth nano material on erythrocyte brittleness, a certain dose of rare earth nano material, with the mass concentrations of 100 g/L and 500 g/Lrespectively, is acted on cavies through four contaminating methods including skin-contacting, oral-feeding, vein-injecting and muscle-injecting. And after some time, the cavies are executed. One of blood indexes, erythrocyte brittleness, is observed. The result shows that rare earth nano materials destroyed the membrane structure of the erythrocytes. And the increase of erythrocyte brittleness means that the materilas may cause some diseases, such as genetic spherocyte increase and self-immune hemolytic anemia and so on.

关 键 词：稀土 纳米 卫生安全性 红细胞脆性 

分 类 号：Q26[生物学—细胞生物学]