HBsAg携带者成人及儿童的遗传物质损伤的研究  

A study of the damage to the HBsAg-carrying adults and children's genetic material

作　　者：王振华[1] 

机构地区：[1]青岛大学医学院生物教研室,266021

出　　处：《中国优生与遗传杂志》2005年第6期31-31,35,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨乙型肝炎病毒(HBV)感染对HBsAg阳性携带者成人及儿童的遗传物质损伤情况。方法用常规法培养淋巴细胞,对20例无症状HBsAg携带者成人及其8例同为携带者的子女的姐妹染色单体互换(SCE)频率进行了分析。结果HBsAg携带者成人SCE频率明显高于正常对照组,差异高度显著(t=3.101,P<0.01),其携带者子女的SCE频率亦明显高于正常对照组,差异高度显著(t=3.161,P<0.01)。结论HBV感染可导致HBsAg携带者成人及儿童的遗传物质不稳定。Objective: To investigate the damage to the genetic material of the HBsAg positive adults and children by the infection of hepatitis B virus(HBV). Methods: The lymphocytes from 20 asymptomatic HBsAg-carrying adults and their 8 children with HBsAg positive were cultured with the routine methods.The frequencies of sister chromatid exchange(SCE) were analysed.Results: The SCE frequency of the HBsAg adult carriers was significantly higher than that of the normal controls(t= 3.101,P<0.01), the SCE frequency of the HBsAg carriers' children was also significantly higher than that of the normal controls(t=3.161,P<0.01).Conclusion: The infection of HBV may cause the instability of the genetic material of the HBsAg-carrying adults and children.

关 键 词：HBSAG携带者 姐妹染色单体互换 乙型肝炎病毒 

分 类 号：R512.6[医药卫生—内科学]