血清IL-6水平与胎膜早破合并宫内感染的关系  

The relationship between maternal serum interleukin-6 concentrations in patients with premature rupture of membrane and chorioamnionitis

作　　者：尹玉竹[1] 谌小卫[1] 侯红英[1] 李小毛[1] 张新玲[1] 

机构地区：[1]中山大学附属第三医院妇产科,广州510630

出　　处：《中国优生与遗传杂志》2005年第6期50-50,63,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨血清IL-6水平与胎膜早破合并宫内感染的关系。方法选取胎膜早破孕妇46例(其中早产早破组22例,足月早破组24例),和产科门诊定期产检的正常孕妇50例为对照组(其中未足月对照组22例,足月对照组28例),用酶联免疫法测定血清IL-6含量,分娩时取部分胎盘胎膜组织送病检。结果胎膜早破孕妇组织学绒毛膜羊膜炎的发生率为52.4%(24/46)。早产早破组与足月早破组血清IL-6水平相比无差异(P>0.05),但均高于对照组(P<0.05=),无论是早产早破组还是足月早破组,有组织学绒毛膜羊膜炎者血清IL-6水平均高于无组织学绒毛膜羊膜炎者及对照组(P<0.05=)。结论血清IL-6水平升高可作为早期诊断胎膜早破合并宫内感染的指标。Objective:To study the relationship between maternal serum interleukin-6(IL-6) concentrations in patients with premature rupture of membrane (PROM) and chorioamnionitis. Methods:Blood samples were collected from the study group consisted of 46 women with PROM(include 22 women at preterm and 24 women at term) and the control group consisted of 50 normal pregnancy women attend the antenatal clinic (include 22 women at preterm and 28 women at term). Serum IL-6 concentrations were measured by enzyme-linked immunosorbent assay. The placent were detected after labor. Chorioamnionitis were diagnosed by histopathologically. Results:There were 24(52.4%)women with histological chorioamnionitis in the study group, The lever of serum IL-6 in the study group were significantly higher than that in the control group(P<0.05), in the study group, no matter women at preterm or at term, the lever of serum IL-6 in the women with histological chorioamnionitis were significantly higher than that women without histological chorioamnionitis and that in the control(P<0.05). Conclusion:Maternal serum IL-6 lever appear to be elevated may prove useful markers for early detection of PROM and chorioamnionitis

关 键 词：胎膜早破 白细胞介素-6 绒毛膜羊膜炎 

分 类 号：R714.433[医药卫生—妇产科学]