肾炎病人血、尿TGF-β_1与肾脏纤维化关系的初步研究  

THE STUDY ON THE CORRELATION BETWEEN TGF-β_1 AND RENAL FIBROSIS IN PATIENTS WITH GLOMERULONEPHRITIS

作　　者：龚莉[1] 韩晓芳[2] 李慧君[2] 马志俊[1] 

机构地区：[1]内蒙古自治区医院肾内科,内蒙古呼和浩特010017 [2]内蒙古自治区医院检验科,内蒙古呼和浩特010017

出　　处：《内蒙古医学院学报》2005年第2期77-79,共3页Acta Academiae Medicinae Neimongol

基　　金：内蒙古自然科学基金项目(990302-1)。

摘　　要：目的:通过检测肾炎病人血、尿中转化生长因子β1(transforminggrowthfactor-β1,TGF-β1)的水平,初步了解其与肾组织纤维化的关系。方法:根据肾炎病人肾组织病理改变、肾功能情况以及肾脏超声检查结果,将表现不同程度肾脏纤维化的病人分为三组,应用特异性酶联免疫吸附试验(enzyme-linkedimmunosorbentassay,ELISA)检测对照组和三组肾炎病人血、尿中的TGF-β1水平。结果:没有肾脏纤维化表现的组和有轻度纤维化表现的组血、尿中TGF-β1水平与对照组比较无明显差异(P>0.05);有明显肾脏纤维化表现的组血TGF-β1水平与对照组相比无差异(P>0.05),但尿中TGF-β1水平高于对照组(P<0.05)。结论:研究提示尿TGF-β1的检测能够作为反映肾组织明显纤维化的标志物,但对于其是否能够准确反映肾组织的轻微纤维化情况,尚有待于更进一步的研究。Objective: To explore the association betwee n transforming growth factor-β_1 (TGF-β_1 ) and renal fibrosis in patients wit h gromerulonephritis by testing its level in serum and urine. Methods: TGF-β_1 in serum and urine were detected by a specific ELISA in normal and three groups of patients with gromerulonephritis. Results: There wa s not a significant difference in the level of TGF-β_1 in serum and urine betw een group Ⅰ patients without renal fibrosis or group Ⅱ patients with slight renal fibrosis and the control (P>0.05); There was not a significant diffe rence in the level of TGF-β_1 in sreum between group Ⅲ patients with severe r enal fibrosis and control (P>0.05), but the level of TGF-β_1 in urine amo ng patients in group Ⅲ was higher than that of control (P<0.05). Con clusion: The results indica ted that urine TGF-β_1 could be the marker of renal fibrosis in gromerulonep hritis. But it awaited further investigation as to whether TGF-β_1 could exact ly reflect slight renal fibrosis.;

关 键 词：转化生长因子Β1 肾小球肾炎 肾纤维化 

分 类 号：R692.3[医药卫生—泌尿科学]