子痫前期-子痫患者血清胱抑素C变化及意义  

The significance of cystatin C measurement in patients with preeclampsia-eclampsia.

作　　者：房桂英[1] 周长浩[1] 张红真[1] 徐淑稳[1] 冯艳萍[1] 

机构地区：[1]河北医科大学第一附属医院妇产科,石家庄050031

出　　处：《现代妇产科进展》2005年第3期222-224,共3页Progress in Obstetrics and Gynecology

摘　　要：目的:研究正常非妊娠妇女,正常妊娠晚期妇女,子痫前期-子痫妇女血清中胱抑素C(CC)的浓度变化规律。方法:选择正常未孕妇女、正常晚期妊娠妇女、子痫前期患者(分轻、中、重度)各30例,用Behringnephelometer100型特种蛋白检测仪采用乳胶颗粒增强的免疫散射浊度法测定血清中CC浓度。结果:孕妇各组血清CC值均较正常未孕者高(P<0·001),重度子痫前期较轻、中度子痫前期及正常晚期妊娠者明显增高(P<0·001),而轻、中度子痫前期及正常晚期妊娠血清CC值无明显区别(P<0·05)。结论:CC是反映子痫前期肾功能损害的良好指标,为CC在产科领域的临床广泛应用提供了理论依据。Objective:To study the changes of serum cystatin C in normal non-pregnant woman,normal late pregnancy woman and preeclampsia-eclampsia. Methods:Thirty normal non-pregnant women,30 normal late pregnant women and preeclampsia-eclampsia women including 30 mild preeclampsia-eclampsia,30 moderate preeclampsia-eclampsia and 30 severe preeclampsia-eclampsia were enrolled in this study.Serum cystatin C was measured by particle enhanced nephelometric immunoassay (PENIA) on the Dade Behring Nephlometer System(BN 100).Results:Serum levels of CC in every group of pregnancy were significantly increased than that in normal non-pregnanct(P<0.001)and severe preeclampsia-eclampsia group was significantly increased than that in normal late pregnancy,mild and moderate preeclampsic-eclampsia group(P<0.001),but there was no significant difference among normal late pregnancy,mild and moderate preeclampsia-eclampsia(P<0.05).Conclusion:Serum CC is a better marker to reflect renal function in preeclampsic-eclampsia,which provides theory basis for serum CC widely being used in obstetrics.

关 键 词：免疫散射浊度法 西司他汀类 妊娠末期 妊娠并发症 

分 类 号：R714.24[医药卫生—妇产科学]