五仁醇固体分散体的制备及体外溶出度研究  

Preparation and dissolution of solid dispersion of Fructus Schisandrae Chinensis extracts

作　　者：赵铁[1] 邱明丰[2] 张永煜[2] 王小荣[2] 陈大为[1] 贾伟[2] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016 [2]上海交通大学药学院,上海200030

出　　处：《中草药》2005年第7期998-1002,共5页Chinese Traditional and Herbal Drugs

摘　　要：目的将五仁醇制成固体分散体,提高五仁醇中有效成分的体外溶出度。方法采用直接将载体材料溶于五仁醇提取液,然后除去溶剂的方法制备了多种五仁醇固体分散体,以五味子甲素为指标成分,研究并比较了它们的表观溶解度和体外溶出度。结果配比为1∶3的五仁醇-聚乙烯吡咯烷酮K 30(PVP K 30)固体分散体中有效成分的表观溶解度比五仁醇胶囊内容物显著提高,达到5.06μg/mL(水);溶出介质(水)中分散(包括溶解)的小于0.22μm的药物高达43.2%。结论五仁醇-PVP K 30固体分散体能明显提高五仁醇中有效成分的表观溶解度和体外溶出度。Objective To prepare Wurenchun solid dispersion of alcohol extracts of Fructus Schisandrae Chinensis so as to improve the dissolution of its active compound in vitro.Methods The Wurenchun solid dispersions were prepared with various carriers and drug/carrier ratios by mixing the carrier in alcohol extractive solution of FSC directly,and the apparent solubility and dissolution of deoxyschisandrin in them were tested and compared.Results The apparent solubility and dissolution of deoxyschisandrin of Wurenchun solid dispersion(extracts: polyvinylpyrrolidone(PVP) K30=1∶3) were increased remarkably to 5.06 μg/mL and 43.2% in water individually,including dispersed and dissolved drug whose particle size is below 0.22 μm,compared with that of the self-prepared Wurenchun capsules.Conclusion Wurenchun solid dispersion made of PVP K30 can remarkably enhance apparent solubility and dissolution of the active compound in vitro.

关 键 词：五仁醇 聚乙烯吡咯烷酮K30 固体分散体 溶解度 溶出度 

分 类 号：R283.3[医药卫生—中药学] R286.02[医药卫生—中医学]