非透析慢性肾功能衰竭患者的微炎症反应与肾功能的关系  

Microinflammatory respone related to renal function in nondialytic chronic renal failure

作　　者：谢恺庆[1] 张绍峰[2] 杨海波[3] 张运凤[1] 

机构地区：[1]广西医科大学第一附属医院血液净化中心,广西南宁530021 [2]广西医科大学第一附属医院检验科,广西南宁530021 [3]广西医科大学微生物与免疫教研室,广西南宁530021

出　　处：《临床荟萃》2005年第14期791-793,共3页Clinical Focus

基　　金：广西壮族自治区卫生厅医药卫生科研基金(桂卫Z2003014)

摘　　要：目的探讨非透析慢性肾功能衰竭(肾衰竭)患者慢性微炎症反应与肾功能的关系.方法测定50例非透析慢性肾衰竭患者慢性炎症指标血C反应蛋白(CRP)、白细胞介素6(IL-6)及肾功能指标,分析它们之间的关系.结果有32%慢性肾衰竭患者CRP超过正常参考值(5 mg/L),内生肌酐清除率(Ccr)＜5 ml/min组的CRP明显高于Ccr≥5 ml/min组(P＜0.05)和对照组(P＜0.05);CRP与IL-6呈明显正相关(r=0.313,P＜0.05);血CRP、IL-6与Ccr呈明显负相关(P＜0.05～0.01),与血清肌酐(SCr)、血尿素氮(BUN)呈明显正相关(P＜0.05、P＜0.01).结论非透析慢性肾衰竭患者存在慢性微炎症状态,慢性微炎症反应与肾功能下降程度密切相关.Objective To investigate the association between chronic microinflammatory indices and renal function in nondialytic chronic renal failure.Methods Serum C-reactive protein(CRP),interleukin-6(IL-6) and renal function indices were determined in 50 chronic nondialytic patients,and the relationship among them was analyzed.Results CRP was >5 mg/L (normal upper range) in 32% of the patients with chronic renal failure.The serum CRP level in Ccr<5 ml/min group was significantly higher than that in Ccr≥5 ml/min group(P< 0.05) and control group(P< 0.05).CRP and IL-6 had significant positive relation (r= 0.313,P< 0.05).CRP and IL-6 were inversely related to creatinine clearance and positively related to blood urea nitrogen(BUN),serum creatinine (SCr)(P< 0.05- 0.01).Conclusion There is chronic microinflammatory state in nondialytic chronic renal failure.Chronic microinflammation is closely correlated with decreased renal function.

关 键 词：炎症 C反应蛋白质 白细胞介素6 肾功能衰竭 慢性 

分 类 号：R692.5[医药卫生—泌尿科学]