蒿甲醚、甘草对实验性弓形虫病的疗效  

STUDIES ON THE EFFECT OF ARTEMETHER AND RADIX GLYCYRRHIZAE IN TREATMENT OF EXPERIMENTAL TOXOPLASMOSIS

作　　者：梁志慧[1] 徐麟鹤[1] 

机构地区：[1]上海医科大学基础医学院寄生虫学教研室

出　　处：《上海医科大学学报》1994年第1期7-10,T001,共5页Journal of Fudan University(Medical Science)

摘　　要：小鼠腹腔接种１万个速殖子，２ｈ后分别灌胃给予：甘草３２ｇ／ｋｇ、甘草１６ｇ／ｋｇ、蒿甲醚２００ｍｇ／ｋｇ、蒿甲醚１００ｍｇ／ｋｇ、乙胺嘧啶５０ｍｇ／ｋｇ及５％淀粉溶液（对照组），连续１４ｄ。甘草各组与对照组小鼠死亡天数无差异。蒿甲醚２００ｍｇ／ｋｇ组的疗效与乙胺嘧啶组接近。图象分析表明：蒿甲醚２００ｍｇ／ｋｇ组的虫体，其周长、面积、体积均数大于对照组说明虫体有肿胀。在透射电镜下，速殖子的核膜消失，染色质减少，对类锥体、棒状体等细胞器无影响。作者首次在实验弓形虫病中证明蒿甲醚２００ｍｇ／ｋｇ的疗效与乙胺嘧啶５０ｍｇ／ｋｇ接近，并探讨了其作用机理。The mice were infected with 10 000 tachyzoites peritoneally.2 hours after infection the mice were divided into 7 groups and administrated by gavage for 14consecutive days:32g/kg of Radix Glycyrrhizae, 16 g/kg of Radix Glycyrrhizae,200 mg/kg of artemether,100 mg/kg of artemether,50 mg/kg of pyrimethamineand 5% of amylum(control). No significant differences in the survival days wereobserved between Radix Glycyrrhizae group and control.The group 200 mg/kgartemether gave the similar effect as the group pyrimethamine. Image analysisshowed that the mean of perimeter,area,sphere volume of tachyzoits treated with200 mg/kg artemether were significantly higher than that of control.UnderTEM partial loss of nulear membrane and decrease of chromatin were observed.No changes was observed in the rhoptries conoid and other organelles.

关 键 词：蒿甲醚 甘草 弓形体病 

分 类 号：R531.805[医药卫生—内科学]