噪声应激对大鼠血浆激素含量的影响  

Effects of the Noise Stress on the Content of Hormone in Rat Blood Plasma

作　　者：胡军祥[1] 姜玉新[2] 赵玉勤[3] 

机构地区：[1]浙江林学院生命科学学院,杭州311300 [2]浙江大学生物技术研究所,杭州310029 [3]嘉兴学院医学院,浙江嘉兴3140002

出　　处：《科技通报》2005年第4期392-395,共4页Bulletin of Science and Technology

基　　金：国家自然科学基金资助项目(39670241);浙江省自然科学基金资助项目(Y304053)

摘　　要：对大鼠分别进行80 dB和100 dB的噪声刺激,并在第1、5、10、15和20 d测定大鼠血浆中有关激素的含量。结果表明:噪声应激引起大鼠血浆中的皮质醇、去甲肾上腺素、肾上腺素、多巴胺及血管紧张素Ⅱ含量明显升高,特别是肾上腺素含量比对照组提高2.5倍。说明噪声应激不仅使下丘脑-垂体- 肾上腺系统、交感神经-肾上腺髓质系统这两条经典应激途径活动加强,而且还有海马与蓝斑-去甲肾上腺素系统、杏仁核促肾上腺皮质激素释放激素神经元和肾素-血管紧张素系统的参与,使“应激系统”的活动加强。这对应激作出生理反应具有重要意义,但若长期维持,最终导致“应激综合征”或生理心理疾病的发生。The rats were respectively stimulated by 80 dB and 100 dB noise, the content of hormone in rat blood plasma was tested in 1、5、10、15 and 20 days. The experimental results showed that the noise stress increased evidently the content of cortisol, noradrenaline(NA), adrenaline(A), dopamine(DA)and angiotensin Ⅱ (AⅡ) in rat blood plasma, especially for the adrenaline content, it was 2.5 times high as the control group. The noise stress enhanced the activities of hypothalamus-pituitary-adrenal system (HPAS), sympathetico-adrenomidullary system (SAMS), hippocampus-nora-drenaline system(HCNAS), locus coeruleus-noradrenaline system(LCNAS), renin-angiotensin system(RAS) and corpus amygdaloideum neuron of corticotropin-releasing hormone(CA-CRH neuron). So the noise stress induced increasing activity of the 'stress system'. This had important significances for the physiological response to the stress, but would result in producing the'stress syndrome'or psychophysiogical desease if lasted too long.

关 键 词：动物生理学 噪声应激 激素 大鼠 

分 类 号：Q954.55[生物学—动物学]