血管紧张素Ⅱ受体拮抗剂治疗高血压左心室肥厚的临床分析  

The clinical analysis of angiotensin Ⅱ receptor blocker in treatment of patients with essential hypertension and left ventricular hypertrophy

作　　者：廖习清[1] 梁海南[1] 董少红[1] 

机构地区：[1]暨南大学医学院附属第二医院深圳市人民医院心内科,广东深圳518020

出　　处：《中国基层医药》2005年第6期677-678,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察血管紧张素Ⅱ受体拮抗剂———缬沙坦(代文)的降压效果及其对高血压合并左心室肥厚的影响。方法对95例轻、中度高血压左心室肥厚患者进行24周的缬沙坦治疗(80～160mg/d,顿服),并对治疗前后的血压、超声多普勒心动图检测结果进行分析。结果经过24周的治疗,血压从165/112mmHg降至130/84mmHg(P<0.01),左室后壁厚度、室间隔厚度、左室心肌重量指数也明显下降(P<0.01)。结论缬沙坦作为血管紧张素Ⅱ受体拮抗剂,可用于治疗轻、中度高血压左室肥厚。Objective To investigate the effect of angiotensin Ⅱ receptor blocker(ARB)-valsartan(diovan) on reducing blood pressure and essential hypertension and left ventricular hypertrophy(LVH).Methods Ninety-five mild-moderate essential hypertensive patients with essential hypertension and LVH received valsartan 80～160mg daily for 24 weeks,and contrasted the blood pressure,echocardiography before and after the treatment.Results Valsartan reduced blood pressure from 165/112mmHg to 130/84mmHg(P<0.01),and the intraventricular septum thickness(IVST) and left ventricular posterior thickness(LVPWT) became obviously thin(P<0.01);Left ventricular mass index(LVMI) was reduced(P<0.01).Conclusion Valsartan as an angiotensin Ⅱ receptor blocker has better effect of treating essential hypertension and LVH.

关 键 词：血管紧张素Ⅱ受体拮抗剂 治疗 高血压 左心室肥厚 临床分析 

分 类 号：R541.3[医药卫生—心血管疾病]