三氧化二砷对人胃癌细胞株转移基因编码蛋白表达影响的研究  

Study on the Effects of Arsenic Trioxide on the Encoding Protein Expressions of Metastatic Gene in Gastric Cancer Cells of Human Body

作　　者：刘淑梅[1] 徐薇[1] 孟祥宇[1] 梁桃[1] 孟昕[1] 

机构地区：[1]哈尔滨医科大学附属第一临床医学院,哈尔滨市150001

出　　处：《中国药房》2005年第13期980-982,共3页China Pharmacy

摘　　要：目的:研究三氧化二砷(As2O3)对人胃癌细胞株nm23、P53基因编码蛋白表达的影响,从而探讨其抗肿瘤作用机制。方法:设立对照组和试验组,以As2O3作用于体外培养的人胃癌细胞株,通过免疫组化技术对nm23和P53基因编码蛋白的表达进行检测。结果:与对照组比较,试验组人胃癌细胞株nm23、P53基因编码蛋白表达减少。结论:As2O3具有下调nm23、P53基因编码蛋白表达作用,从而发挥抗肿瘤效应。OBJECTIVE:To study the effects of arsenic trioxide(As 2 O 3 )on the encoding protein expressions of nm23and P53in gastric cancer cells and to study the anti-canecer mechanism of which in the tumor.METHODS:A control group and a test group were set up.The expressions of gene coding proteinum nm23and P53of the gastric cancer cells cultured in vitro by the action of As 2 O 3 were determined by immunohistochemistry method.RESULTS:The expression levels of nm23and P53in gastric cancer cells have been lowered compared with the control group.CONCLUSION:As 2 O 3 can exert its anti-tumor effect by decreasing the expression of gene coding proteinum of nm23and P53.

关 键 词：三氧化二砷 人胃癌细胞株 基因表达 

分 类 号：R965[医药卫生—药理学]