抗癫痫药物治疗对血脂水平影响的研究  

Effect of Long-term Antiepleptic Drugs on Serum Lipids Level in Patients with Eplilepsy

作　　者：金莉蓉[1] 汪昕[1] 马昱[1] 张昱雯[1] 

机构地区：[1]复旦大学附属中山医院神经内科,上海200040

出　　处：《中国临床医学》2005年第3期538-539,共2页Chinese Journal of Clinical Medicine

摘　　要：目的:探讨长期服用抗癫痫药物(卡马西平、苯妥英钠、丙戊酸钠)对血脂水平的影响。方法:测定已确诊为癫痫的48例患者(卡马西平组16例,苯妥英钠组16例,丙戊酸钠组16例)的血脂水平,并与健康对照组16例进行比较。结果:1)血脂浓度与癫痫本身无相关性;2)长期服用卡马西平和苯妥英钠后总胆固醇(TC)和甘油三酯(TG)、高密度脂蛋白(HDL-c)、载脂蛋白A(Apo-A)和脂蛋白(a)[LP(a)]明显增高(p<0.05),低密度脂蛋白(LDL-c)无变化,且LP(a)随治疗时间的延长浓度明显增高(r=0.74,p<0.05),丙戊酸钠对血脂无影响。结论:长期抗癫痫药治疗能使血脂浓度增高,因此需长期监测血脂水平,预防动脉粥样硬化。Objective: To assess the effect of serum lipids levels in patients with epilepsy who had been receiving long-term carbamazepine, sodium pheyntom,valproate therapy. Methods; Serum total cholesterol, triglycendes, low-density lipoprotem cholesterol, high- density lip oprotein cholesterol, apolipoprotein A, and apohpoprotem B and apolipoprotem E and lipoprolem (a) concentrations were measured in 48 epilectic patient taking anticonvulsant drugs for longer than 12 months. 16 healthy, sex-and age-matched people served as controls. Results: Epilepsy itself did not influences the level of serum lipids. TC.TG, HDL-C, Apo-A, Lp(a) were significantly increased after antiep ileptic therapy with CBZ and PHT(p<0. 05), and LDL-c,Apo-B,Apo-E did not changed. VPA did not influence the level of serum lipids. Conclusion: These Data indicate that proplonged anticonvulsant treatment could increase serum lipids concenratoms and it may be useful to measure the levels routinely in order to prevent atherosclerosis in epileptic patients taking anticonvulsant drugs.

关 键 词：癫痫 抗癫痫药物 血脂 

分 类 号：R971.6[医药卫生—药品]