氨基磺酸催化、光异构化合成富马酸二甲酯  

Synthesis of dimethyl fumarate catalyzed by amino sulfonic acid and isomerized under light

作　　者：俞善信[1] 文瑞明[2] 张鲁西[1] 

机构地区：[1]湖南师范大学化学化工学院,湖南长沙410081 [2]湖南城市学院化学与环境工程系,湖南益阳413049

出　　处：《化工科技》2005年第3期17-19,共3页Science & Technology in Chemical Industry

基　　金：湖南省科技计划资助项目(03JZY3034);湖南省教育厅科研基金资助项目(01C022)。

摘　　要：马来酸酐和甲醇在氨基磺酸催化下发生酯化反应,所得产物马来酸二甲酯在光和溴存在下异构化成富马酸二甲酯。n(马来酸酐)∶n(甲醇)∶n(氨基磺酸)=1:5:0.2,回流反应6h,该酯收率达90.3%,该法具有操作方便,反应温和,产品收率高的优点。By using amino sulfonic acid as catalyst, esterification reaction first took place between maleic anhydrite and methanol. Then the intermediate, dimethyl maleate was isomerized into dimethyl fumarate under light and in the presence of bromine. The yield of the ester could reached 90.3% under the molar ratio of maleic anhydrite, methanol and amino sulfonic acid was 1∶5∶0.2,and refluxing reaction for 6?h. The method has advantages of simple operation, mild reaction conditions and higher product yield.

关 键 词：富马酸二甲酯 合成 氨基磺酸 催化 马来酸酐 甲醇 酯化 异构化 

分 类 号：O623.6[理学—有机化学] TQ225.2[理学—化学]