β3-AR基因多态性与高血糖人群膳食干预效果  

Study on β3-adrenergic receptor gene polymorphism and effect of dietary intervention in community hyperglycemia population

作　　者：左辉[1] 翟成凯[1] 姜玲[1] 赵宝华 王翠华 陈燕明 冯妙仁 王兆麟[6] 许雯 

机构地区：[1]东南大学公共卫生学院,南京210009 [2]南京市白下区中华医院 [3]南京市秦淮区门西医院 [4]南京市鼓楼区挹江门卫生院 [5]南京市下关区小市医院 [6]南京市玄武区医院 [7]南京市鼓楼区中医院

出　　处：《中国公共卫生》2005年第7期807-809,共3页Chinese Journal of Public Health

基　　金：江苏省卫生厅预防医学基金项目(Y200203);达能营养中心膳食营养研究与宣教基金项目(DIC2003-10)

摘　　要：目的探讨β3AR基因多态性与高血糖人群膳食干预效果的关系,为糖尿病的膳食干预提供遗传学依据。方法从南京市8个社区抽取233名汉族高血糖者,随机分为复合干预组(154人)和对照组(79人)。干预组给予粗粮干预和进行健康进座,对照组不采取任何措施,试验周期6个月。结果干预组Trp/Trp基因型者体质指数(BMI)、腰臀比(WHR)、舒张压(DBP)、空腹血糖(FBG)、血总胆固醇(TC)水平明显降低,高密度脂蛋白胆固醇(HDLC)水平明显上升(P<0.05);Trp/Arg基因型组BMI、WHR、FBG水平明显降低,HDLC水平明显上升(P<0.05)。Arg/Arg基因型组无明显变化。此外,Trp/Trp型人群的BMI、WHR和FBG下降的干预效果明显大于Trp64Arg型和Arg/Arg型,而Trp64Arg型人群的这3项指标下降又明显大于Arg/Arg型(P<0.05)。结论高血糖人群膳食干预效果因β3AR基因型不同而有差异,其中,Trp/Trp人群对膳食干预效果最佳,Trp/Arg次之,而Arg/Arg效果较差。ObjectiveTo find out the relationship between a mutation in the β3-adrenergic receptor gene and the susceptibility of hyperglycemia population to dietary intervention,and to provide genetic evidence for intervention on diabetes mellitus.Methods 233 hyperglycemia individuals of Han were screened from 8 communities in Nanjing,and they were separated into multiplex nutritional intervention(154 individuals)and control group(79 individuals)at random.The former were provided with coarse good grain and health education for 6 months,and no any intervention for the latter.Results Body mass index(BMI),waist to hip ratio(WHR),diastolic blood pressure(DBP),fasting blood glucose(FBG),total cholesterol(TC) decreased significantly,while high density lipoprotein cholesterol(HDL-C)increased significantly(P<0.05)in the individuals with Trp/Trp of intervention group.BMI,WHR,FBG decreased significantly,HDL-C also increased significantly(P<0.05)in the ones with Trp/Arg.There was no significant changes in the ones with Arg/Arg.Moreover,susceptibility of change for BMI,WHR and FBG in Trp/Trp genotype carriers was greater than that in Trp/Arg or Arg/Arg genotype carriers.And,susceptibility of change for these 3 indexes in Trp/Arg genotpe carriers was greater than those in Arg/Arg genotype carriers(P<0.05).Conclusion Susceptibility of hyperglycemia population to dietary intervention varies with different genotypes of the β3-adrenergic receptor gene.Susceptibility of individuals with Trp/Trp to dietary intervention is the best of all,Trp/Trp takes second place,while Arg/Arg is relatively little.

关 键 词：Β3-AR 基因多态性 高血糖 膳食干预 

分 类 号：R181.3[医药卫生—流行病学]