慢性磷中毒患者血清中8种物质检测分析  

Analysis on laboratory examination for serum of eight materials in patients with chronicity phosphorus poisoning

作　　者：李溥[1] 岑荣光[2] 罗毅 莫兴菊[2] 韦绍英[2] 

机构地区：[1]黔南民族医学高等专科学校检验系生化教研室,都匀558003 [2]黔南民族医学高等专科学校附属医院核医学科 [3]福泉市第二人民医院

出　　处：《中国公共卫生》2005年第7期811-812,共2页Chinese Journal of Public Health

基　　金：贵州省卫生厅科技资助项目

摘　　要：目的了解慢性磷中毒患者血清中8种物质含量变化,探讨其在慢性磷中毒发病机制中的作用。方法应用放射免疫法对患者血清透明质酸(HA)、IV型胶原(IV-C)、胆酸(CG)、肿瘤坏死因子(TNF)、转化生长因子-α(TGFα)、白细胞介素-1(IL-1)、白细胞介素-6(IL-6)和白细胞介素-8(IL-8)进行测定和分析。结果慢性磷中毒组与对照组比较HA、IV-C、CG、TGFα、IL-1、IL-6、IL-8明显升高(P<0.01),而TNF明显下降(P<0.01);分层分析,重度组与对照组比较,差异有统计学意义(P<0.01)。结论慢性磷中毒患者血清中8种物质含量测定,可以了解磷对机体的损害程度和范围,对慢性磷中毒的防治具有重要指导作用。Objective To investigate the serum levels of eight materials changes in patients and to understand their mechanism.Methods Serum contents of hyaluronic(HA),type IV collagen(IV-C),cholalic acid(CG),tumor necrosis factor(TNF),transforming growth Factor-α(TGFα),interleukin-1(IL-1),interleukin-6(IL-6)and interleukin-8(IL-8)were detected by radioimmunoassay and were analyzed.Results Compared with control the serum contents of HA,IV-C,CG,TGFα,IL-1,IL-6 and IL-8 rose significantly(P<0.01).while analyzed by delamination,there was marked difference between the serious group and control(P<0.01).Conclusion Radioimmunoassay detecting of the above-mentioned eight materials in patiens with chronicity phosphorus poisoning plays an important role in judging the range and degree of the body and in directing treatment and preventation.

关 键 词：慢性 磷中毒 放射免疫测定法 

分 类 号：R135.1[医药卫生—劳动卫生]