类固醇激素所致小鼠胸腺急性退缩的病理学观察  

Pathological study of sccondary thymic atrophy causcd hy steroid hormone in mice

作　　者：林久治[1] 熊健[1] 呼守生[1] 雷捷[1] 张致宏 蔡玲玲[1] 

机构地区：[1]北京首都儿科研究所

出　　处：《中华病理学杂志》1994年第1期29-30,T009,共3页Chinese Journal of Pathology

摘　　要：用类固醇激素治疗健康的ＢＡＬＢ／Ｃ鼠，经病理观察发现，给药２４小时后胸腺开始出现继发性萎缩，萎缩的程度与用药的剂量和时间相关；停约后７天，除个别动物外各实验组的胸腺重量、光镜和电镜改变均恢复正常。表明继发性胸腺急性退缩在解除致病因素后，一般可得恢复。ccording to the pathological observations on BALB/c mice after being given steroid hormone,the following results were obtdined:secondary thymic atrophy could be observed 24 hours after steroid therapy.The degree of atrophy correlated with the amount of medication and duration of tnerapy;the weight and pathological changes under light and electron microscope examination almost returned to normal 7 days after the drug was stopped except in individual animals. Our study indicated that secon-dary atrophy of the thymus can be reversed after elimination of the pathogenic factor.

关 键 词：激素 胸腺疾病 病理学 

分 类 号：R583.02[医药卫生—内分泌]