总和电位与外淋巴瘘的关系  

Relationship Between Summating Potentials and Perilymphatic Fistula

作　　者：成晋川[1] 何凌汉[1] 顾瑞[1] 

机构地区：[1]第三军医大学大坪医院,中国人民解放军总医院耳鼻咽喉科,解放军军医进修学院

出　　处：《中华耳鼻咽喉科杂志》1994年第5期278-281,T054,共5页Chinese Journal of Otorhinolaryngology

摘　　要：圆窗膜划破后记录了４０只豚鼠２４小时内耳蜗电图变化，其中３０只作了组织学观察。结果表明：外淋巴疹后１～３小时内１００％动物出现负和电位，而组织学检查有积水样改变的动物仅为３０％，外淋巴瘘后２４小时１０只动物ＣＡＰ反应阈及Ｎ＿１潜伏期有所恢复，其中６只负和电位消失。认为负和电位并非膜迷路积水特有的电生理表现，推测负和电位的出现或增大是内耳毛细胞可逆性损害的指征，基底膜机械性位移很难作为负和电位增大的主要原因。还就外淋巴瘘后膜迷路积水形成的机理进行了讨论。Serial electrocochleogram(ECochG ) recordings were obtained within 24 hours from 40 guinea pigs with experimentally induced PLF,and the cochlears of 30 guinea pigs(60 ears)were histopathologically observated under light microscope.一SP occured in 100%experimented ears within 1～3 hours after PLF , but distention of Ressner’s membrane was found only in 30% ones. CAP thresholds and Nl latencies of 10 animals were improved,accompanying disappearance of一SP in 6 of the 10 animals in 24 hours after PLF. It is presumed that一SP is not a specifically electro-physiologic indicator of ELH, and that the generation of一SP may chiefly result from reversible dam-age of cochlear hair cells,The mechanical factor of basilar membrane displacement can hardly be con-sidered as a main cause of SP abnormality. The mechanism of the ELH following PLF was also dis-cussed.

关 键 词：膜迷路积水 诱发反应 外淋巴瘘 

分 类 号：R764.04[医药卫生—耳鼻咽喉科]