复方丹参注射液对急性心肌梗死t-PA、PAI和GMP-140的影响  

The Clinical Observation on the Influence of Composite Salvia Miltiorrhiza Injection (复方丹参注射液) on the Levels of t-PA, PAI and GMP-140 of Patients with AMI

作　　者：林辉文[1] 彭环庆 

机构地区：[1]广东省佛山市南海区中医院,佛山528200

出　　处：《中国中医急症》2005年第7期615-616,共2页Journal of Emergency in Traditional Chinese Medicine

基　　金：广东省佛山市卫生局科研课题(No.2001302)

摘　　要：目的观察急性心肌梗死(AMI)患者治疗前后血浆组织纤溶酶原激活物(t-PA)、纤溶酶原激活物抑制物(PAI)和血小板α-颗粒膜蛋白-140(GMP-140)含量的动态变化及复方丹参注射液的疗效。方法将AMI患者70例随机分为治疗组和对照组,两组均予西医常规治疗,治疗组加用复方丹参注射液。两组分别于治疗前、治疗后4、12周测定血浆t-PA、PAI和GMP-140浓度,并观察其严重心律失常、心绞痛、心功能不全的发生情况。结果治疗组和对照组治疗后t-PA、PAI和GMP-140浓度均接近正常,12周后治疗组t-PA水平低于对照组,PAI和GMP-140水平高于对照组;其严重心律失常、心绞痛、心功能不全的发生率均显著低于对照组。结论复方丹参注射液治疗AMI患者的疗效确切,并能降低其严重心律失常、心绞痛、心功能不全的发生率。Objective:To observe the changes of t-PA,PAI and GMP-140 in plasma before and after the treatment,and the curative effect of composite salvia miltiorrhiza injection (复方丹参注射液) for AMI.Methods:70 patients with AMI were randomly divided into the treatment group and the controlled group.Patients in both groups were given the usual treatment of WM,while those in the treatment group were given composite salvia miltiorrhiza injection additionally.Every patient was determined the levels of t-PA,PAI and GMP-140 in plasma before and after the treatment.Results:The levels of t-PA,PAI and GMP-140 in plasma of patients in both groups were approaching to normal,while level of t-PA of which in the treatment group after 12 weeks,treatment were significant lower than of the controlled group,and the levels of PAI and GMP-140 were higher than of the controlled one.The occurrence of serious arrhythmia,angina pectoris and cardiac insufficiency of the treatment group were lower correspondingly.Conclusion:There are exact effect of composite salvia miltiorrhiza injection to the patients of AMI,which could decrease the incidence rate of serious arrhythmia,angina pectoris and cardiac insufficiency.

关 键 词：急性心肌梗死 复方丹参注射液 t—PA PAI GMP-140 

分 类 号：R542.22[医药卫生—心血管疾病]