温血心麻痹液心肌保护作用的实验研究  

Experimenatal study of myocardium protection withwarm blood cardioplegia

作　　者：陈若为[1] 汪曾伟[1] 徐凤翔[1] 

机构地区：[1]中国人民解放军沈阳军区总医院心脏外科,空军郑州医院

出　　处：《中华外科杂志》1994年第5期306-309,T049,共5页Chinese Journal of Surgery

摘　　要：作者对离体大鼠心脏灌注不同心麻痹液，观察停跳缺血缺氧１２０分钟后心率、左室收缩压、心输出量、心肌含水量、钙含量及进行组织病理检杏。对３７℃缺血缺氧２０分钟的离体兔心灌注不同心麻痹液，观察心麻痹液灌注期间不同时段心脏动静脉液ｐＨ、氧含量差值，自体动脉血再灌注２０分钟心脏左心室收缩压与心率的乘积。右房采用测ＣＰＫ、ＭＤＡ含量，心肌ＡＴＰ、ＣＰ含量，组织病理检查。结果表明：温血心麻痹液在为停跳心肌供氧，保存和增加心肌能量储备，避免缺血缺氧再灌注损伤，缓冲酸中毒，保护心功能等方面均能发挥较满意的心肌保护作用。AbstractThe present paper has shown the effects of my-ocardial protection of isolated rat heart which were in-fused with different kinds of cardioplegia, and made tobe arrested in the state of ischemia and absence of oxy-gen for 120 min. The heart rate,left ventricular con-straction pressure and cardiac output volume, the my-ocardium water content and calcium content and patho-logical examination of myocardium were observed. Theisolated rabit heart under the circumstances of is-chemia and absence of oxygen at 37℃ for 20 min Ob-servations of the different kinds of cardioplegia. wasobserved that the different of pH and oxygen contentbetween artery and vein of the heart during the infusionof cardiopiegia,the value of left ventricular constractionpressure multiplied by heart rates after reperfusionwith autologous artery blood for 20 min. The values ofCPK and MDA in right atrial blood the ATP AND CPvolum of myocardium and pathologic study of my-ocardium were carried out,The results demonstratedthat the warm blood cardioplegia had a better myocar-dial protection effect in supplying sufficient oxygen tomyocardium during heart arrest, preserving and in-creasing energy store; controlling reperfusion in juryafter ischemia, buffering acidosis and preserving heartstatus function, Therefor it has great value for improv-ing the safety of the patients with complex and highrisk heart diseases in perioperation.

关 键 词：体外循环 心肌保护 温血心麻痹液 

分 类 号：R654.1[医药卫生—外科学]