激素性股骨头缺血坏死发病机制的实验研究  

Experimental study on mechanism of steroid-inducedavascular necrosis of femoral head

作　　者：王坤正[1] 毛履真[1] 胡长根 贺西京[1] 陈君长[1] 杨哲[1] 金辽沙[1] 刘安庆[1] 

机构地区：[1]西安医科大学第二附属医院骨科

出　　处：《中华外科杂志》1994年第9期515-517,T097,共4页Chinese Journal of Surgery

摘　　要：作者进行了实验性激素性股骨头缺血性坏死的发病机制研究。６４只白兔分为两组，实验组４８只，每周皮下注射醋酸氢化可的松８ｍｇ／ｋｇ；对照组１６只，每周皮下注射生理盐水０．３２ｍｇ／ｋｇ，两组动物同样条件下喂养。结果显示：激素药物能引起股骨头骨细胞发生脂肪变性和坏死，小血管脂肪栓塞。肥大的骨髓内脂肪细胞压迫股骨头内小静脉引起毛细血管血液瘀滞。毛细血管生长和再生受到抑制。AbstractThe authors adopted an animal model to observethe pathogenic mechanism of steroid- induced avascularnecrosis of the femoral head. Sixty-four white rabbitswere divded into two groups:hydrocortisone acetate(8mg / kg ) was hypodernllcally given to 48 experimen-tal animals and 0.32mg/kg of normal salineto 16 rab-bits for control, Two groups of animal were fed andkept in the same condition, The resuIts showed thatapplication of the steriod drug could produce fat degen-eration and necrosis of osteocvtes and fat embolism inthe small blood vessels of the femoral head.The ab-normal hypertrophied fat cells in the bone marrowcompressed small veins in the femoral head resulting inblood stasis of the capillaries, thus growth and regen-erahion of the capillary were inhibited.

关 键 词：股骨头坏死 缺血 激素性 

分 类 号：R681.802[医药卫生—骨科学]