The Self-catalytic Esterification Reaction of O-Phosphoryl Serine Derivative  

作　　者：JinTangDU YahMeiLI ZhongZhouCHEN ShiZhongLUO YuFenZHAO 

机构地区：[1]KeyLaboratoryofBioorganicPhosphorusChemistry＆ChemicalBiology（MinistryofEducation）,DepartmentofChemistry,TsinghuaUniversity,Beijing100084

出　　处：《Chinese Chemical Letters》2005年第7期856-858,共3页中国化学快报（英文版）

基　　金：The authors would like to thank the financial supports from the National Natural Science Foundation of China(No.20272032 and No.20320130046);Ministry of Education of China and Tsinghua University.

摘　　要：O-Phosphoryl serine derivative can perform self-catalytic esterification reaction in the mixture of CH3OH and CHCl3 at the room temperature. The phosphoryl group participation was the key step of the esterification. This type of reactions were proposed through an intermediate of mixed phosphoric-carboxylic anhydride that might provide a clue to the function of the phosphoryl group in the phosphorylated enzymes and in the prebiotic synthesis of protein.

关 键 词：O-Phosphoryl serine self esterification phosphoryl group participation. 

分 类 号：O629.711[理学—有机化学] O621.256.4[理学—化学]