The Interaction between Propranolol and Gold Nanoparticles and its Analytical Application  

作　　者：HongYingDUAN FangCHEN XinPingAI ZhiKeHE 

机构地区：[1]CollegeofChemistry＆MolecularSciences,WuhanUniversity,Wuhan430072

出　　处：《Chinese Chemical Letters》2005年第7期947-950,共4页中国化学快报（英文版）

基　　金：The authors acknowledge the support from the National Natural Science Foundation of China(No.20275028);973 Program(No.2002CB2118);863 Program(No.2002AA2Z2004).

摘　　要：The addition of propranolol induced the aggregation of gold nanoparticles, and increased Rayleigh light scattering (RLS) intensity greatly. The interaction between them was studied by RLS spectrum, UV-Vis spectrum and transmission electron microscopy (TEM). Based on these results, a novel method was proposed for propranolol assay. With the combination of solid phase microextraction (SPME), the proposed method was successfully applied to determine propranolol in urine.

关 键 词：PROPRANOLOL gold nanoparticles resonance light scattering SMPE. 

分 类 号：R972[医药卫生—药品] O614.123[医药卫生—药学]