应用不同剂量米非司酮中期引产对胎儿脐血染色体稳定性影响的临床研究  

Effect of mifepristone on chromosome stability of fetal in the second trimester abortion

作　　者：苏光[1] 魏丽惠[1] 

机构地区：[1]北京大学人民医院妇科,100044

出　　处：《中国妇产科临床杂志》2005年第4期256-258,306,i002,共5页Chinese Journal of Clinical Obstetrics and Gynecology

摘　　要：目的探讨米非司酮用于中期引产对胎儿姐妹染色单体交换率(SCE)和微核(MN)率的影响。评估不同剂量米非司酮对母亲及胎儿染色体稳定性影响。方法选择符合研究条件的中期引产患者120例,随机分为4组,1～4组分别口服米非司酮0、150、200、300mg加水囊引产,于产后取脐血进行SCE交换试验和细胞分裂阻滞法MN试验。结果各组胎儿脐血SCE率进行单因素方差分析(P>0.05)差异无显著性。各组胎儿脐血MN率经KruskalwallisH非参数检验(P>0.05),差异无显著性。结论孕妇应用150、200、300mg剂量米非司酮引产,不会引起其子代SCE和MN增加。Objective To study the effect of different dose of mifepristone on the sister chromatid exchange (SCE) rate and micronucleus (MN) rate in fetus during the second trimester abortion. Methods A total of 120 healthy pregnant women, gestational age of 16～24 weeks, were randomized into four groups: group1 without mifepristone, group2, 3 and 4 given 150 mg, 200 mg and 300 mg of mifepriston, respectively. All of the women underwent water-bag abortion at 48 hours after mifepriston taken. The umbilical blood was collected after abortion, then the SCE assay and cytokinesis blocked MN assay were applied. Results The SCE rate of umbilical blood in group 1 to 4 was (3.59±0.68)%, (3.82±0.46)%, (3.97±0.51)% and (3.82±0.48)%, respectively. No significant difference was found pairwise (P>0.05); neither was the MN rate (P>0.05). Conclusions Pregnant women taken 150mg, 200mg or 300mg of mifepristone orally do not increase the SCE rate and MN rate of fetus.

关 键 词：米非司酮 中期引产 胎儿 脐血 姐妹染色单体交换率 微核 

分 类 号：R719.3[医药卫生—妇产科学]