针灸对缺血性脑血管病颈动脉粥样硬化患者血脂、血流变、LPO和SOD、ET和CGRP的影响  

Influence of Acupuncture and Moxibustion on Lipid, Blood Flow Deformation, LPO, SOD, ET and CGRP in Patients with Carotid Atherosclerosis due to Ischemic Cerebrovascular Diseases

作　　者：王伟志[1] 王占奎[2] 赵建国[1] 傅立新[1] 

机构地区：[1]天津中医学院第一附属医院针灸部,天津300193 [2]天津中医学院,天津300193

出　　处：《上海针灸杂志》2005年第7期19-23,共5页Shanghai Journal of Acupuncture and Moxibustion

基　　金：天津市卫生局课题(200047);天津科技成果[S(2004)1091]

摘　　要：目的观察针灸对缺血性脑血管病颈动脉粥样硬化(CAS)患者的临床疗效。方法将90例颈动脉粥样硬化患者随机分为针灸观察组、针刺对照组、药物对照组各30例。临床观察症状和体征疗效以及血液流变学、血脂、脂质过氧化物(LPO)及超氧化物歧化酶(SOD)活性、内皮素(ET)及降钙素基因相关肽(CGRP)的变化。结果针灸明显降低患者血瘀证候积分,改善患者的临床症状;对患者全血粘度、全血还原粘度、血浆粘度等指标改善显著,经针灸治疗后患者的ESR、IR、ESRK、PAG及总积分均有明显下降(P<0.05,P<0.01);针灸对TC及HDL具有明显的改善作用;能够显著减弱LPO氧化活性,升高SOD活性;针灸能够显著降低ET水平,明显升高CGRP水平。结论针灸能明显改善患者的血瘀症状和体征;改善血液流变性,调整微循环状况;通过改善脂质代谢,软化动脉血管;通过对ET及CGRP含量的调整,改善血管本身的舒缩功能;通过对SOD及LPO的影响,减少自由基对血管壁的损伤;以上作用共同起到抑制颈动脉粥样硬化的功效。Objective To investigate the clinical efficacy of acupuncture and moxibustion in patients with carotid atherosclerosis (CAS) due to ischemic cerbrovascular diseases. Methods Ninety patients with carotid atherosclerosis due to ischemic cerebrovascular diseases were randomly divided into acupuncture-moxibustion observation, acupuncture control and medication control groups, 30 cases each. Observed clinically were the symptoms and signs, blood flow and deformation, blood-glycol,lipid peroxidase (LPO), Superoxide dismutase (SOD), endothelin (ET) and calcitonin gene related peptide (CGRP).Results Acupuncture and moxibustion markedly decrease blood-stagnancy syndrome score and improve the clinical symptoms and indices such as whole blood viscosity, whole blood reduction viscosity and plasma viscosity in the patients. ESR, IR, ESRK, PAG and the total score significantly dropped in the patients after acupuncture and moxibustion (P<0.05,P<0.01). Acupuncture and moxibustion had an obvious improving effect on TC and HDL and could markedly reduce LPO oxidative activity, increase SOD activity, lower ET level and raise CGRP level.Conclusion Acupuncture and moxibustion can markedly improve the patient’s clinical symptoms and signs and blood flow and deformation property, regulate microcirculation, soften arterial walls through ameliorating lipid metabolism, improve vasomotor function through regulating ET and CGRP contents and reduce the injury of free radicals to vascular walls through influencing SOD and LPO. The above effects function to inhibit carotid atherosclerosis.

关 键 词：针灸疗法 脑缺血 颈动脉粥样硬化 

分 类 号：R246.6[医药卫生—针灸推拿学]