低剂量雄激素对心肌梗死后心衰成年雄兔血清雄激素水平的影响  

Effects of low dose androgen treatment on serum androgen levels in male adult rabbits postinfarction CHF model

作　　者：樊瑾[1] 李小鹰[1] 娄卫民[1] 沈正[1] 

机构地区：[1]解放军总医院老年心内科,北京市100853

出　　处：《中国康复理论与实践》2005年第6期415-416,共2页Chinese Journal of Rehabilitation Theory and Practice

基　　金：总后卫生部临床高新技术重大项目建设基金[No.2002卫医字第18号(32号)]。

摘　　要：目的观察低剂量雄激素十一酸睾酮(TU)和脱氢表雄酮(DHEA)对心肌梗死后心衰雄兔血清雄激素水平的影响.方法对48只4～5月龄健康雄性新西兰大白兔随机行冠状动脉结扎(n=40)或假手术(n=8).3周后将存活的30只模型兔随机分为3组分别给予TU 3 mg/kg/2周肌肉注射(TU组,n=10)、DHEA 3 mg/kg/d口服(DHEA组,n=10)或安慰剂(MI组,n=10)治疗3个月.分别于第0、3、15周观察血清雄激素水平.结果模型兔3周时左室射血分数为(47.6±4.5)%与假手术组的(66.7±5.8)%有显著性差异( P＜0.05),应用小剂量TU/DHEA治疗12周后血清游离睾酮升至正常范围,硫酸脱氢表雄酮浓度高于假手术组( P＜0.05).结论本研究中采用的TU和DHEA补充剂量接近心肌梗死后雄兔需要的生理剂量.ObjectiveTo investigate the effects of low dose testosterone undecanonate (TU) and dehydroepiandrosterone (DHEA) on serum androgen levels in male adult rabbits postinfarction congestive heart failure (CHF) model.Methods48 male 4～5 months old New Zealand rabbits were randomly assigned to ligation of first branch of left coronary artery (n=40) or sham operation (n=8). 3 weeks later, 30 survived model rabbits were randomly treated with TU 3 mg/kg per 2 weeks intramuscular injection (TU group, n=10), DHEA 3 mg/kg/d oral (DHEA group, n=10) or placebo (placebo group, n=10) for 3 months. Serum androgen changes were recorded at 0th, 3rd and 15th week.ResultsAt 3rd week after peration, left ventricular ejection fraction of model animals was 47.6±4.5% lower than that of the sham group (66.7±5.8%) ( P<0.05). Serum free testosterone level of model animals returned to normal ranges after low dose TU or DHEA treatment, otherwise DHEAS level was higher than the sham group ( P<0.05).ConclusionThe doses used in this research reached physiological dosage to male adult rabbits in postinfarction CHF model.

关 键 词：兔 雄激素 心力衰竭 

分 类 号：R542.2[医药卫生—心血管疾病]