痢疾杆菌菌群及药敏特点分析  

Analysis of the group and the rate of drug sensitivity in 254 strains of dysenteric bacilli.

作　　者：秦恩强[1] 赵敏[1] 周志平[1] 王凝芳[1] 

机构地区：[1]解放军302医院感染一科,北京100039

出　　处：《中国实用内科杂志》2005年第7期617-618,共2页Chinese Journal of Practical Internal Medicine

摘　　要：目的研究解放军302医院2003-2004年痢疾杆菌菌群分布和药敏特点,指导临床治疗。方法经粪培养筛选出254株痢疾杆菌,用生化和血清学方法鉴定群和血清型。采用Kirby-Bauer法检测病原耐药性。结果在254株痢疾杆菌中,福氏志贺菌最多有196株,宋内志贺菌有58株。在福氏志贺菌血清型中,F4占首位,有106株。总的药敏结果耐药率复方新诺明最高,氨苄青霉素次之;对氟喹诺酮类抗生素耐药性较高,三代头孢菌素、磷霉素耐药率低。结论2003-2004年解放军302医院细菌性痢疾患者中,菌群以福氏志贺菌占优势,血清型以F4为主。氟喹诺酮类抗生素仍是最有效的抗生素之一,但有一定耐药性。若氟喹诺酮类抗生素无效,可选用三代头孢菌素或磷霉素。Objective To investigate the distribution and the rate of drug sensitivity of dysenteric bacilli in Beijing from 2003 to 2004 so as to guide the choice of antibacterial. Methods This was a retrospective study. 254 shigellae were cultured from stool. The group and serotype were identified with biochemical and serologic tests. Kirby-Bauer method was used to detect the drug sensitivity rate. Results There were 196 strains of Shigellae flexneri and 58 Shigellae sonnei a-mong 254 strains of shigellae. The number of F4 was 106 strains in Shigellae flexneri. SMZ resistance rate was the highest ; fluoroquinolones, the third generation cephalosporins and phosphonomycins had much more sensitivity. The drug sensitivity rate to fluoroquinolones between Shigellae flexneri and Shigellae sonnei was different. Conclusion In 2003 and 2004, Shigellae flexneri is the dominant group in 254 Shigellae in Beijing. F4 is the dominant serotype among Shigellae flexneri. On antibacterial effects,fluoroquinolones is one of the most effective drug, but had a certain resistance rate. If the pathogen is resistant to fluoroquinolones, the third generation cephalosporins or phosphonomycins can be used.

关 键 词：细菌性痢疾 分布 药敏试验 

分 类 号：R5[医药卫生—内科学]