辛伐他汀治疗颈动脉粥样硬化疗效观察  

Observation on the curative effect of simvastatin treat carotid atheroma.

作　　者：陈杭军[1] 余毅[1] 林雪香[1] 

机构地区：[1]广东省东莞市人民医院,523018

出　　处：《中国实用内科杂志》2005年第7期621-622,共2页Chinese Journal of Practical Internal Medicine

摘　　要：目的观察辛伐他汀对颈动脉粥样硬化的临床疗效。方法选择东莞市人民医院2003-01-2004-06门诊或住院患者106例伴有颈动脉粥样硬化的患者,随机分为2组。治疗组56例,服用辛伐他汀20mg,每晚1次;对照组50例,服用肠溶阿司匹林100mg,每日1次,疗程4个月。于治疗前后用彩色多普勒超声检测颈动脉内膜-中层厚度及斑块大小。结果治疗组颈动脉内膜-中层厚度及斑块大小治疗后明显减小(P<0.05),对照组治疗前后差异无显著性(P>0.05)。结论辛伐他汀可以明显减轻颈动脉粥样硬化病变,可作为治疗颈动脉粥样硬化的常规用药。Objective To observe the curative effect of simvastatin to treat carotid atheroma. Methods 106 patients with carotid atheroma were randomly divided into two groups. The treatment group( n=56) was given orally 20 micro-gram of simvastatin every night, while the matched control group( n = 50) was given 100 microgram of aspirin enteric-coated everyday for 4 months. Results After four months of follow-up, the carotid artery inner-intermediate thickness and the speckle's size,examined by the color Doppler, were obviously decreased ( P <0.05) in the treatment group,but there was no obvious change in the control group ( P>0.05). Conclusion Simvastatin can obviously ameliorate the carotid atheroma. It can be served as one of the normal selections for treating the carotid atheroma.

关 键 词：辛伐他汀 颈动脉粥样硬化 治疗 

分 类 号：R5[医药卫生—内科学]