2型糖尿病性脂肪肝瘦素等相关因素的分析  

The correlative factors analysis of leptin in type 2 diabetic fatty liver.

作　　者：杨淑芳[1] 王玉君[1] 

机构地区：[1]重庆医科大学第二附属医院内分泌科,400010

出　　处：《中国实用内科杂志》2005年第7期625-627,共3页Chinese Journal of Practical Internal Medicine

摘　　要：目的探讨瘦素(leptin)、谷胱甘肽过氧化物酶(GSH-Px)等因素与2型糖尿病(2DM)性脂肪肝的关系。方法报告了2003-10-2004-06重庆医科大学第二医院检测23例2型糖尿病性脂肪肝,30例2DM患者和30例健康者血清leptin,GSH-Px,血脂及体重指数(BMI),体脂含量(FAT%)水平,作比较相关研究。结果(1)2型糖尿病性脂肪肝甲状腺球蛋白(TG)、BMI、FAT%明显高于其它两组。(2)3组leptin、GSH-Px差异显著,免疫电泳(leptin)与FAT%、年龄相关,GSH-PX与年龄、HDL相关。结论(1)TG、BMI、FAT%是影响2型糖尿病性脂肪肝发生的主要因素。(2)2型糖尿病性脂肪肝和2DM存在“瘦素抵抗”,受肥胖、年龄影响。(3)2DM抗氧化酶降低,与年龄、HDL关系密切。Objective To explore the relationship of leptin、 Glutathione peroxidase (GSH-Px) and other correlative factors with type 2 diabetic fatty liver. Methods From 2003-10 to 2004-01, we examined leptin、GSH-Px、 blood fat in the serum and BMI、FAT% in 23 cases of type 2 diabetic fatty live、30 cases of type 2 diabetic inpatients and 30 healthy people. Compare their level and analyse the correlation. Results (1)The TG、BMI、FAT% of type 2 diabetic fatty liver patients were significantly higher than that of the others groups. (2)Leptin and GSH-Px of each group had significant changes. Leptin was correlative with FAT% and age. GSH-Px was correlative with age and HDL. Conclusion (1)TG、 BMI and FAT% are important risky factors. (2)There are leptin resistance in type 2 diabetic fatty liver and type 2 diabetes patients and it is influenced by obesity and age. (3)The antioxidant enzyme in the serum of type 2 diabetes patients is reduced and is related with age and HDL.

关 键 词：2型糖尿病性脂肪肝 瘦素 谷胱甘肽过氧化物酶 

分 类 号：R5[医药卫生—内科学]