血糖无创监测中近红外漫反射光谱技术的研究  

Achievement of the Noninvasive Measurement for Human Blood Glucose with NIR Diff usion Reflectance Spectrum Method

作　　者：张洪艳[1] 丁东[2] 宋立强[3] 谷琳娜[1] 杨鹏[1] 唐玉国[1] 

机构地区：[1]中国科学院长春光学精密机械与物理研究所,吉林长春130033 [2]吉林大学通信工程学院,吉林长春130012 [3]云南师范大学物理与电子信息学院,云南昆明650092

出　　处：《光谱学与光谱分析》2005年第6期882-885,共4页Spectroscopy and Spectral Analysis

基　　金：中国科学院长春光学精密机械与物理研究所二期创新项目

摘　　要：将近红外漫反射光谱技术应用到血糖无创监测中。实验使用Nexus 870傅里叶红外光谱仪及其光纤附件采集了6名不同年龄健康志愿受试者大拇指指尖的近红外漫反射光谱。对光谱进行了平滑、基线校正和一次求导预处理,采用偏最小二乘(PLS)方法在含有葡萄糖吸收峰的75 0 0～85 0 0cm- 1 波段建立同一个体、相同年龄段的不同个体以及不同年龄段的不同个体的校正模型。采集漫反射光谱的同时抽适量的血样在75 2型紫外光栅分光光度计上标定血糖的实际值,并对校正模型计算值和实际标定值进行了比较,结果表明个体建模的相关性很好,相关系数达到0 90 4 71以上,均方差小于0 171。The noninvasive measurement of human blood glucose was achieved with NIR diffusion reflectance spectrum method. The thumb finger-tip NIR diffusion reflectance spectra of six different age healthy volunteers were collected using Nexus-870 and its NIR fiber port smart accessory. The test was implemented with changing the blood glucose concentration for the limosis and satiation of every volunteer. The calibration model was set up using PLS method with the smoothing, baseline correction and first derivatives pretreatment spectrum in the 7 500-8 500 cm(-1) region for single volunteer, the same age combination and that of different age. When the spectrum was obtained, the actual blood glucose value of every spectrum sample was demarcated using ultraviolet spectrophotometer. The correlation between the calibration value and true value for single volunteer is better than that for the combination of volunteers, the correlative coefficients are all over 0.904 71, RMSECs are all less than 0.171.

关 键 词：近红外漫反射光谱 血糖 PLS 预处理 

分 类 号：O657.3[理学—分析化学]