盐酸尼卡地平缓释微丸的制备及其溶出度研究  

The Study of Preparation of Nicardipine Hydrochloride Sustained-release Pellets and Its Release In Vitro

作　　者：刘志林[1] 杨春娜[1] 柳雪瑜[1] 翁桂闽[1] 

机构地区：[1]广东外语外贸大学门诊部,广东广州510420

出　　处：《中国药业》2005年第7期24-25,共2页China Pharmaceuticals

摘　　要：目的:制备盐酸尼卡地平缓释微丸,并考察影响其溶出度的因素。方法:采用滚动凝聚法制备,用紫外分光光度法测定溶出度。结果:盐酸尼卡地平体外溶出度随着膜厚度及聚乳酸分子量增大而显著减小。结论:聚乳酸可用于制备口服盐酸尼卡地平缓释制剂。Objective:To prepare nicardipine hydrochloride sustained-release pellets,and to research factors affecting the release rate in vitro. Methods:The rolling coacervation method was used to prepare nicardipine hydrochloride sustained-release pellets, and ultraviolet spectrometry was used to assess the release of nicardipine hydrochloride in vitro.Results:The release rate of nicardipine hydrochloride decreased considerably with the growth of the thickness of membrane and Mw of PLA.Conclusion:PLA can be used to prepare oral nicardipine hydrochloride sustained-release.

关 键 词：盐酸尼卡地平 聚乳酸 缓释微丸 溶出度 

分 类 号：R944.9[医药卫生—药剂学] R972.4[医药卫生—药学]