细胞免疫功能在川崎病发病机制中的作用  

Study on Cellular Immune Function in Kawasaki Disease

作　　者：郑淑梅[1] 刘文彬[1] 王太森[1] 张宏伟[1] 周颖[1] 

机构地区：[1]成都军区总医院儿科,成都610083

出　　处：《实用儿科临床杂志》2005年第7期641-642,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的探讨川崎病患儿细胞免疫功能。方法分别采用碱性磷酸酶抗碱性磷酸酶法(APAAP)、ELISA法和双抗体夹心酶联免疫吸附法测定川崎病60例患儿外周血T细胞亚群、血清白细胞介素-2(IL-2)及可溶性白细胞介素-2受体(sIL-2R)水平。结果与对照组比较,川崎病患儿急性期外周血CD3+及CD8+百分率明显下降,CD4+百分率、CD4+/CD8+、血清IL-2及sIL-2R水平明显升高,以上免疫学指标变化在并冠状动脉病变者更为显著。结论川崎病患儿急性期存在细胞免疫功能过度活化及免疫调节功能紊乱。Objective To study the cellular immune function in children with kawasaki disease(KD).Methods T lymphocyte subcytes,levels of serum interleukin 2(IL-2) and soluble interleukin 2 receptor(sIL-2R) were determined by APAAP,ELISA met-hods,and a double-antibody “sandwich” enzyme-linked immunosorbent assay respectively in 60 cases.Results During the acute stage of KD,the percentage of CD4 +,the ratio of CD4 +/CD8 +,levels of IL-2 and sIL-2R increased markedly,while the percentage of CD3 + and CD8 + decreased significantly compared with the controls.These changes were more remarkable in patients subsequently developed coronary artery aneurysms than in those with normal appearing coronary artery.Conclusion Marked activation of cellular immune function and immune regulation disorders develop in acute stage of KD patients.

关 键 词：川崎病 T细胞亚群 白细胞介素2 受体 白细胞介素-2 

分 类 号：R725.4[医药卫生—儿科]