多糖衍生物治疗大鼠实验性骨质疏松效果观察(英文)  

Effect of marin algae polysaccharide derivant on osteoporotic model of the rats induced retinoic acid

作　　者：司予北[1] 高革[1] 

机构地区：[1]新乡医学院实验中心,河南新乡453003

出　　处：《新乡医学院学报》2005年第4期302-304,共3页Journal of Xinxiang Medical University

基　　金：河南省科委资助项目

摘　　要：目的观察多糖衍生物治疗骨质疏松的疗效。方法40只6月龄雌性大鼠用维甲酸诱导产生骨质疏松模型,用多糖衍生物治疗。大鼠被随机分成两组,实验组每只每天口服10mg多糖衍生物,对照组每只每天口服10mg葡萄糖,通过形态学评估多糖衍生物的疗效。结果经多糖衍生物治疗后实验组大鼠平均骨小梁数、平均骨小梁厚度和平均骨小梁面积明显大于对照组(P<0.01)。结论海藻多糖衍生物可增加骨重量,对维甲酸诱导产生骨质疏松有预防和治疗作用。Objective To observe the effect of marin algae polysaccharide derivant on the osteoporotic model of the rats.Methods Forty six-month-old female Wistar rats were selected to duplicate the osteoporotic model induced by retinoic acid and performed with marine algae polysaccharide derivant.The rats were randomly divided into two groups:experiment group treated with 10 mg marine algae polysaccharide derivant10mg per day by oral,control group treated with 10 mg glucose per day by oral.The effect of marine algae polysaccharide derivant on osteoporosis were evaluated by morphometry.Results After intake of polysaccharide,the mean trabecular plate density (Tb.N),the mean trabecular plate thickness(Tb.Th),and the percent trabecular area (Tb.Ar%) of the experiment group, which were treated by polysaccharide were significantly increased more than that of the control group model(P<0.01).Conclusion These results indicate that polysaccharide can increase bone mass and has a therapeutic and preventional effect on the osteoporotic model of the rats induced by retinoic acid.

关 键 词：大鼠 骨质疏松 海藻多糖衍生物 组织学 

分 类 号：Q95-33[生物学—动物学]