壳糖止血海绵的药效学研究  

A pharmacological study of chitosan hemostatic sponge

作　　者：宋炳生[1] 李汉宝[1] 陈家英[2] 

机构地区：[1]南京军区南京总医院药学部,江苏南京210002 [2]南京药物研究所,江苏南京210000

出　　处：《医学研究生学报》2005年第7期601-602,共2页Journal of Medical Postgraduates

基　　金：南京市2002年第八批科技发展计划资助项目(批准号:20028006)

摘　　要：目的:研究壳糖止血海绵对家兔耳静脉创口的吸渗、止血作用及皮肤烫伤后促进愈合的作用,为临床用药提供实验依据。方法:用刀片划破血管,分别用壳糖止血海绵、明胶海绵和纱布压迫出血处,30s后去除海绵和纱布,观察止血效果;在家兔烫伤创面,分别敷壳糖止血海棉、明胶海棉和纱布,观察10天内脱痂情况。结果:与明胶海绵组比较,壳糖止血海绵止血时间明显缩短(P<0.05);促进创口愈合,创面脱痂时间缩短。结论:壳糖止血海绵对创口的止血、促愈合疗效确切。Objective: To investigate the extravasate sponging and hemostatic property of chitosan hemostatic sponge on the wound of otic vein of rabbit, and its healing effect on the scald of rabbit skin, for clinical application. Methods: Lacerating the otic vein of rabbit with bistoury and promptly pressing the wound with chitosan hemostatic sponge, gelatin sponge or gauze, respectively, the hemostatic effect was observed by uncovering each 30 seconds. Spreading chitosan hemostatic sponge, gelatin sponge or gauze, respectively, on the scalds of rabbit skin, the decrustation (pulling off scab) was observed within 10 days. Results: Comparing with the group of gelatin sponge, the group of chitosan hemostatic sponge showed significant differences in bleeding time and wound healing (P<0.05). Conclusion: Chitosan hemostatic sponge provided hemostatic property and would be helpful to accelerate wound healing.

关 键 词：壳聚糖 止血海绵 止血剂 

分 类 号：R973.1[医药卫生—药品]