配合物[Ni(EDTB)]·2Cl·CH_3OH·C_2H_5OH的合成、晶体结构及SOD模拟活性的研究  

Synthesis and Crystal Structure of Complex [Ni(EDTB)]·2Cl·CH_3OH·C_2H_5OH and Its Superoxide Dismutase Mimic Activity

作　　者：覃事栋[1,2] 冯思思 张红梅[1] 朱苗力[1] 杨频[1] 

机构地区：[1]山西大学分子科学研究所化学生物学与生物工程教育部重点实验室 [2]吉首大学化学系吉首416000

出　　处：《化学学报》2005年第13期1155-1160,i001,共7页Acta Chimica Sinica

基　　金：国家自然科学基金(No.20471033);山西省自然科学基金(No.20051013)资助项目

摘　　要：报道六齿配体N,N,N',N'-四(2-苯并咪唑亚甲基)-1,2-乙二胺(EDTB)及单核镍(II)配合物[Ni(EDTB)]?2Cl?CH3OH?C2H5OH的合成、晶体结构和SOD模拟活性.该配合物为三斜晶系,P1空间群,a=1.0931(2)nm,b=1.1693(2)nm,c=1.6756(4)nm,α=76.042(3)°,β=88.787(3)°,γ=72.044(3)°,V=1.9740(7)nm3,Dc=1.321g/cm3,Z=2,F(000)=824,μ=0.670mm-1.最终因子R[I>2σ(I)]:R1=0.0611,wR2=0.1497;R(全部数据):R1=0.0870,wR2=0.1604.结构分析表明,镍(II)分别与配体中的四个苯并咪唑氮和两个亚胺基氮配位形成扭曲的八面体构型.改良的邻苯三酚自氧化活性测定表明,该配合物具有较高的SOD模拟活性.The title complex Ni(EDTB)?2Cl?CH3OH?C2H5OH [EDTB=N,N,N',N'-tetrakis-[(2-benzimi- dazolyl)methyl]-1,2-ethanediamine] has been synthesized and characterized by elemental analysis and single crystal X-ray diffraction method. The crystal of mononuclear Ni(II) complex belongs to triclinic system with space group, P 1, a=1.0931(2) nm, b=1.1693(2) nm, c=1.6756(4) nm, α=76.042(3)°, β=88.787(3)°, γ=72.044(3)°, V=1.9740(7) nm3, Dc=1.321 g/cm3, Z=2, F(000)=824, μ=0.670 mm-1. The final R[I> 2σ(I)]: R1=0.0611, wR2=0.1497 and R (all data): R1=0.0870, wR2=0.1604. The nickel(II) atom of the cation has distorted octahedral coordination geometry and is six-coordinated by six nitrogen atoms: four ni- trogen atoms of the benzimidazole groups and two tertiary amine nitrogen atoms from the ligand. The su- peroxide dismutase mimic activity of the complex has been determined by means of modified Marklund method to show that the title complex has a high superoxide dismutase mimic activity.

关 键 词：镍配合物 合成 晶体结构 超氧化酶歧化酶模拟活性 EDTB 

分 类 号：O641.4[理学—物理化学]