交联聚乳酸中空微球的制备与表征  

Preparation and Characterization of Cross-linked Hollow Poly(lactic acid) Microspheres

作　　者：江兵兵[1] 高长有[1] 沈家骢[1] 

机构地区：[1]浙江大学高分子科学与工程学系,杭州310027

出　　处：《高等学校化学学报》2005年第7期1384-1386,M011,共4页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:90206006;50425311);国家重点研究发展规划项目(批准号:G1999054305)资助.

摘　　要：Poly(lactic acid) macromonomer with a double bond at its end was synthesized by ring open polymerization of lactide catalyzed by stannous chloride in the presence of allyloxylethanol(AOE) as a co-initiator. Its molecular weight was decreased along with the adding amount of AOE. Initiated by an oxidation-reduction system, e.g. K-2S-2O-8 and Na-2SO-3, the poly(latic acid) macromonomers were copolymerized with divinylbenzene and methacrylic acid in a water-in-oil-in-water emulsion manner to produce hollow microspheres with a size of hundreds nanometers. Their hollow structure was confirmed by transmission electron microscopy. Infrared spectroscopy measurement shows that the remainings of the microspheres after tetrahydrofuran extraction, constituting roughly 20 of the sphere′s mass, contained all the initial monomer components. This provides a new pathway for fabricating biodegradable hollow microspheres with rather smaller size, which may find diverse applications in the fields of drug delivery, tissue engineering and nanotechnology.Poly(lactic acid) macromonomer with a double bond at its end was synthesized by ring open polymerization of lactide catalyzed by stannous chloride in the presence of allyloxylethanol(AOE) as a co-initiator. Its molecular weight was decreased along with the adding amount of AOE. Initiated by an oxidation-reduction system, e.g. K-2S-2O-8 and Na-2SO-3, the poly(latic acid) macromonomers were copolymerized with divinylbenzene and methacrylic acid in a water-in-oil-in-water emulsion manner to produce hollow microspheres with a size of hundreds nanometers. Their hollow structure was confirmed by transmission electron microscopy. Infrared spectroscopy measurement shows that the remainings of the microspheres after tetrahydrofuran extraction, constituting roughly 20 of the sphere′s mass, contained all the initial monomer components. This provides a new pathway for fabricating biodegradable hollow microspheres with rather smaller size, which may find diverse applications in the fields of drug delivery, tissue engineering and nanotechnology.

关 键 词：乳液聚合 聚乳酸 中空微球 

分 类 号：O631[理学—高分子化学]