尿β_2－微球蛋白和N－乙酰－B－D氨基葡萄糖苷酶测定与肾小球疾病预后的关系  

THE RELATIONSHIP BETWEEN URINURY β_2-M AND NAG ENZYME AND DEFINITIVE RESULT OF GLONCOCELOPATHY

作　　者：黄利基[1] 何国玲[1] 

机构地区：[1]暨南大学医学院附属医院儿科

出　　处：《暨南大学学报（自然科学与医学版）》1994年第2期48-52,共5页Journal of Jinan University(Natural Science & Medicine Edition)

摘　　要：检测５２例原发性肾小球疾病尿β_２－微球蛋白（β_２－Ｍ）和Ｎ－乙酰－β－Ｄ氨基葡萄糖苷酶（ＮＡＧ），探讨其与肾小球疾病恢复过程与预后关系，并设健康儿对照。结果示尿β_２－Ｍ的与ＮＡＧ均值在肾小球疾病全病程均高于对照组，差异有非常显著性意义，从肾小球疾病组内不同病期看，急性肾炎（ＡＧＮ）不同病期均值随疾病恢复而递减，最后接近正常值；肾病综合征（ＮＳ）缓解初期均值较活动期高，以后逐渐下降，但始终未降至正常。２９例病程４个月内其均值已正常，但仍见波动。从肾小球疾病恢复期测定值看，尿β_２－Ｍ、ＮＡＧ仍未恢复正常者分别为４４％、５４．７％。表明肾小球疾病恢复过程中，尽管临床症状已消失，尿蛋白已阴转，仍有近一半病例肾功能尚未恢复正常。尿β_２－Ｍ的与ＮＡＧ检测可反映肾小管和肾实质受损程度，若尿β_２－Ｍ与ＮＡＧ持续升高，可能提示病情迂延或慢性经过。Urinury β_2-M and NAG were detrmined on 52 cases of original glocrolus disease in orderto study the relationship between the process of recovey of gloncocelopathy and its definitive re-sult.The result were compared with that of healthy children cascontral.The results showed thatthe average rates of both lhe urinury β_2-M and NAG through the whole process ofgloncocelopathy were higher than these of control group.The difference wes striking.At vari-ous stages of the disease,average rate of β_2-M and NAG of AGN decreases as one recovers.Finally,the late comes very dose to the normal status.Average rate of urinury β_2-M andNAG of Nisi the early,relieving stage was higher than that of the active stage.While it contin-ues to drop gradually afterwards,but the rat would not come down to normal status.Thoughstill remaining unstable,within four months.The average rate of the twenty-nine cases,has comedown to normal statub. From the date of the recovering period in gloncocelopathy,patients withurinucy β_2-M and NAG unrecovered were 44% and 54.7% respectively,showing that dispitethe disappecerance of clinical symptoms and urinury protein,50% of them still have come notto normal,Since the date of urinury β_2-M and NAG shows theactrual degree of impairmentof golmaruli and tubules continuotus inceasing of urinury β_2-M and NAG might indicate ex-tension of the illness or the disease was turning to chronic type.

关 键 词：肾小球疾病 急性 肾炎 NAG 

分 类 号：R692.6[医药卫生—泌尿科学]