基于原子力显微镜技术的单个生物大分子压弹性研究  

Investigation of the compression elasticity of single biomacromolecules by atomic force microscopy

作　　者：周星飞[1,2,3] 孙洁林[4] 米丽娟[1,2] 王化斌[1] 胡钧[1] 

机构地区：[1]中国科学院上海应用物理研究所 [2]中国科学院研究生院,北京100039 [3]宁波大学物理系,浙江宁波315211 [4]上海交通大学BioX生命科学中心

出　　处：《电子显微学报》2005年第3期238-242,共5页Journal of Chinese Electron Microscopy Society

基　　金：国家自然科学基金资助项目(No.10335070;No.10304011).~~

摘　　要：单个生物大分子力学性质已经成为一个新兴的研究领域,近几年来由于单分子技术的不断发展,这个领域取得了很多突破性的进展。本文介绍了基于原子力显微镜技术的几种单分子压弹性测量技术及这些技术的具体应用,同时也简要阐述了这些技术的局限性。另外对这个领域的发展也进行了初步地探讨。The study of the mechanical properties of single biomacromolecules has emerged as a new field in which great advances have been made recently due to the developments in single molecular experimental techniques.Here we introduced some measurement techniques based on the atomic force microscopy for compression elasticity of single molecules,and demonstrated the concrete applications and the limitations of these techniques.In addition,the advances in this exciting field were also prospected.

关 键 词：生物大分子 压弹性 原子力显微镜 测量方法 

分 类 号：Q71-3[生物学—分子生物学]