心钠素和精氨酸加压素对血液透析患者高血压的影响  

EFFECT OF CHANGES IN PLASMA ATRIAL NATRIURETIC PEPTIDE AND ARGININE VASOPRESSIN ON HYPERTENSION IN PATIENTS DURING HEMODIALYSIS

作　　者：孟建中[1] 罗南萍[1] 王成海[1] 

机构地区：[1]中国人民解放军济南军区总医院血液净化中心,第二军医大学神经生物教研室

出　　处：《中华内分泌代谢杂志》1994年第3期160-160,165,166,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：采用放射免疫学方法测定血液透析患者和正常人血浆心钠素（ＡＮＰ）及精氨酸加压素（ＡＶＰ）的浓度。结果：慢性肾功能衰竭（ＣＲＦ）患者血浆ＡＮＰ和ＡＶＰ水平明显高于正常人（Ｐ＜０．０１）；血透后血压正常组随着透析、超滤，血浆ＡＮＰ和ＡＶＰ浓度下降，但高血压组ＡＶＰ水平明显增高，并与血压上升、血钠改变呈显著正相关（分别为ｒ＝０．７８，Ｐ＜０．０１；ｒ＝０．６３，Ｐ＜０．０５）。提示血透患者高血压发病除与ＣＲＦ时血容量增多和肾素－血管紧张素系统活性增加外，还与透析液内钠浓度刺激血浆ＡＶＰ水平增高有关。The changes in plasma atrial natriuretic peptide(ANP) and arginine vasopressin(AVP)in 33 patients with chronic renal fail-ure(CRF)during hemodialysis were studied by means of specific radioimmunoassay. The results showed that the levels of plasmaANP and AVP in the patients with CRF were significantly elevated. After hemodialysis the levels of plasma ANP and AVP in thecases with normal blood pressure fell to the normal levels, but the level of plasma AVP in the cases with high blood pressure gradu-ally elevated and was closely correlated with the elevation of both blood pressure and plasma sodium concentration(r=0. 78,P<0. 01 and r=0. 63,P<0. 05 respectively). The hypertension was related to the change in sodium concentration of the dialysing flu-id,which stimulated an elevation in plasma AVP level.

关 键 词：高血压 血液透析 心钠素 精氨酸加压素 

分 类 号：R544.102[医药卫生—心血管疾病]