瘢痕疙瘩和增殖性瘢痕的超微结构观察  

ABSTRACTSOBSERATION OF THE ULTRASTRUCTURES OF THE KELOID AND HYPERTROPHIC SCAR

作　　者：周慧君[1] 汪铮[1] 

机构地区：[1]上海第二医科大学附属第九人民医院整复外科

出　　处：《中国修复重建外科杂志》1994年第3期175-177,T011,共4页Chinese Journal of Reparative and Reconstructive Surgery

摘　　要：对１４例瘢痕疙瘩和７例增殖性瘢痕的超微结构进行了观察分析。该两种病变均可见到不同时期的成纤维细胞、巨噬细胞和疏密不等的胶原微纤维以及呈不同闭塞状态的微血管。多数成纤维细胞功能很活跃，胞浆内充满了大量扩张的粗面内质网和发达的高尔基复合体，胶原微纤维排列紊乱。但在瘢痕疙瘩中还常见到肌纤维母细胞。其胞质中除了粗面内质网和高尔基复合体以外，还可见大量的肌微丝、密体、密斑以及不完整的基板。该特征拟作鉴别瘢痕疙瘩和增殖性瘢痕的依据。he ultrastructures of 14 keloids and 7 hypertrophic scars were examined by electron micrascopy.Both lesions were found to be comprised of fibroblasts, macrophages, microfi brils of collagen andmicrovessels which were partly or completely obliterated. Most fibroblasts were of active cell types.They contained abundant coarse endoplasmic reticulum and prominent Golgi complexes. The fibrils inthe lesions were irtegularly arranged. Meanwhile myofibroblasts were often seen in the keloid.In thecytoplasm of the myofibroblasts, in addition to coarse endoplasmic reticulum and Golgi complexes,many fine myofilaments, dense theies, dense potches and disrupted basal lamina were present.Thesecharacteristic features might help to differentiate keloid from hygertrophic scar.

关 键 词：瘢痕疙瘩 增殖性瘢痕 肌纤维母细胞 超微结构 

分 类 号：R619.6[医药卫生—外科学]