道诺霉素和去炎松对实验性眼内细胞增生的抑制  

INHIBITION OF EZPERIMENTAL INTRAOCULAR CELLULAR PROLITERATION BY DAUNOMYCIN AND TRIAMCINOLONE

作　　者：胡丹[1] 惠延年[1] 马吉献[1] 

机构地区：[1]第四军医大学西京医院眼科

出　　处：《中华眼底病杂志》1994年第4期229-231,T016,共4页Chinese Journal of Ocular Fundus Diseases

摘　　要：以往的实验证实增殖性玻璃体视网膜病变（ＰＶＲ）炎症期给以道诺霉素效果有限。我们在巨噬细胞注入兔玻璃体后６天再注入道诺霉素５μｇ，采用３Ｈ－胸腺嘧啶放射自显影观察了眼内细胞增生率，并与去炎松和两药联合的作用进行了比较。在２８天时，道诺霉素组、去炎松组、联合用药组及对照组视网膜脱离率分别为３３．３％、１６，１％、８．３％和８３．３％（Ｐ＜０．０１）。放射自显影观察，道诺霉素使１、２周的标记细胞数明显减少（与对照组比分别为１８．８±３．２对３５．７±３．４；５２．１±８，０对８１．３±１４．６．Ｐ＜０．０１）：而去大松及联合用药使炎细胞和标记细胞都明显减少。由此证实在ＰＶＲ炎症期应用去炎松、细胞增生期应用道诺霉素或联合用药可防治牵拉性视网膜脱离。ur previous experiments showed limited resuIts of treatment with daunomycin whengiven at the inflammatory stage of proliferative vitreoretinopathy(PVR induced bymacrophages in rabbits. In the present study,we observed the inhibition of intraocular cellu-lar proliferation in the same model by daunomycin which was injected in a dosage of 5 μ96days after intravitreal macrophage injection,withH-thymidine autoradiography.The efficacyof daunomycin was also compared with that of triamcinolone,and combined triamcinlone anddaunomycin. The retinal detachment occurred in 33.3%,16.1%,8.3%and83.3%(P<0.01)of the eyes treated with daunomycinltriamcinolone,combined drugs and the control groups,respectiveiy. Autoradiography revealed a singnificantly decreased number of labelled nuclei ofproliferative cells on days 7 and 14 in daunomycin-treated eyes(compared to controls,18. 8±3. 2 vs 35.7±3.4;52.1±8.0 vs 81.3±14.6,P<0.01,respectively).Significantly decreasednumbers of inflammatory cells and labelled cells were also noted in eyes treated with triamci-nolone and combined drugs. The results suggest that daunomycin given at the proliferativestage,and triamcionlone given at the inflammatory stage of PVR, or combined drugs can pre-vent traction retinal detachment.

关 键 词：视网膜脱落 增殖性玻璃体 视网膜病变 去炎松 

分 类 号：R965[医药卫生—药理学] R774.13[医药卫生—药学]