Clinical Observation on the Aggressive Lipid-lowering Treatment with Simvastatin on the Aged Patients with Coronary Artery Disease  

作　　者：谢英 卜聪亚 周玉杰 

机构地区：[1]Department of Geriatric Cardiology, Beijing Anzhen Hospital Affiliated of Capital University of Medical Sciences,Beijing 100029, China

出　　处：《South China Journal of Cardiology》2005年第1期53-56,62,共5页岭南心血管病杂志（英文版）

摘　　要：Objectives To find out the efficient dose and safety of simvastatin (Zocor) on the aged patients with coronary artery disease (CAD) for aggressive lipid-lowering treatment. Methods Select 95 aged patients with CAD combined with primary hyperlipemia and give them 20 mg/day of simvastatin for treatment. According to the therapeutic target of serum total cholesterol (TC) and low-density lipopro- tein cholesterol (LDL-C) regulate the dosage of simvas- tatin in follow-up. Observe 12~18 months. Results After treatment, the TC, LDL-C and triglycerides(TG) of the patients reduced by 40% , 52% and 26% respectively, while there was no significant change in high-density lipoprotein cholesterol (HDL-C). The apolipoprotein Al arose by 14.4% , while the apolipoprotein B lowered by 25.0%. The ratio of LDL-C to HDL-C was reduced to 1.96. In the 6th month, the 12th month and the 18th month, respectively, 86%, 93% and 95% of the patients took 10 mg/day of simvastatin and the result was their TC mg/dL (3.7 mmol/L) and LDL-C mg/dL(1.8 mmol/L). There was no special side-effect. Multi-factor analysis indicated the age of the patients was a significant factor affecting the adjustment of the dosage of simvastatin. Conclusions The therapeutic result of simvastatin on the aged patients with CAD for aggressive lipid-lowring treatment is definite, safe and the dose is lower as well.Objectives To find out the efficient dose and safety of simvastatin (Zocor) on the aged patients with coronary artery disease (CAD) for aggressive lipid-lowering treatment. Methods Select 95 aged patients with CAD combined with primary hyperlipemia and give them 20 mg/day of simvastatin for treatment. According to the therapeutic target of serum total cholesterol (TC) and low-density lipopro- tein cholesterol (LDL-C) regulate the dosage of simvas- tatin in follow-up. Observe 12~18 months. Results After treatment, the TC, LDL-C and triglycerides(TG) of the patients reduced by 40% , 52% and 26% respectively, while there was no significant change in high-density lipoprotein cholesterol (HDL-C). The apolipoprotein Al arose by 14.4% , while the apolipoprotein B lowered by 25.0%. The ratio of LDL-C to HDL-C was reduced to 1.96. In the 6th month, the 12th month and the 18th month, respectively, 86%, 93% and 95% of the patients took 10 mg/day of simvastatin and the result was their TC mg/dL (3.7 mmol/L) and LDL-C mg/dL(1.8 mmol/L). There was no special side-effect. Multi-factor analysis indicated the age of the patients was a significant factor affecting the adjustment of the dosage of simvastatin. Conclusions The therapeutic result of simvastatin on the aged patients with CAD for aggressive lipid-lowring treatment is definite, safe and the dose is lower as well.

关 键 词：Coronary heart disease Hypercho- lesterolemia Simvastatin Therapeutics 

分 类 号：R541.4[医药卫生—心血管疾病]